caa a22 4500 465739822 CHVBK 20180323111805.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02368444 doi (NATIONALLICENCE)springer-10.1007/BF02368444 Experimental determination of the force required for insertion of a thermoseed into deep brain tissues [Elektronische Daten] [J. Molloy, R. Ritter, M. Grady, M. Howard III, E. Quate, G. Gillies] Our laboratories are developing a new technique for delivering localized hyperthermia to deep-seated brain tumors. In this technique, a spherical thermoseed is stereotactically navigated through the brain and tumor tissues via the noncontact application of an external magnetic force. The force required to produce motion of a 3 mm diameter sphere through in vitro brain tissues was measured to be 0.07 ± 0.03 N. This result was obtained from a series of experiments performed on whole brain specimens extracted from adult canines. Data were also taken with a 3 mm × 3 mm cylinder and a 5 mm sphere. An experimental procedure simulating physiological conditions was developed prior to testing. Evaluations of systematic effects included determinations of the calibration uncertainties, tests of the dependence of the measured force on temperature, and studies of the effects of method of storage of the tissue specimens. The results obtained are compared with (and confirmed by) two different series of experiments performed in vivo on adult canines and with another series of experiments using brain phantom gelatin. Pergamon Press plc, 1990 Implant nationallicence Force nationallicence Magnetic nationallicence Insertion nationallicence Brain nationallicence Molloy J. Department of Physics, University of Virginia, Charlottesville, Virginia aut Ritter R. Department of Physics, University of Virginia, Charlottesville, Virginia aut Grady M. Department of Neurological Surgery, University of Washington, Seattle, Washington aut Howard III M. Department of Neurological Surgery, University of Washington, Seattle, Washington aut Quate E. Department of Nuclear Engineering and Engineering Physics, University of Virginia, Charlottesville, Virginia aut Gillies G. Department of Nuclear Engineering and Engineering Physics, University of Virginia, Charlottesville, Virginia aut Annals of Biomedical Engineering Kluwer Academic Publishers 18/3(1990-05-01), 299-313 0090-6964 18:3<299 1990 18 10439 https://doi.org/10.1007/BF02368444 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02368444 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Molloy J. Department of Physics, University of Virginia, Charlottesville, Virginia aut NATIONALLICENCE 700 1- Ritter R. Department of Physics, University of Virginia, Charlottesville, Virginia aut NATIONALLICENCE 700 1- Grady M. Department of Neurological Surgery, University of Washington, Seattle, Washington aut NATIONALLICENCE 700 1- Howard III M. Department of Neurological Surgery, University of Washington, Seattle, Washington aut NATIONALLICENCE 700 1- Quate E. Department of Nuclear Engineering and Engineering Physics, University of Virginia, Charlottesville, Virginia aut NATIONALLICENCE 700 1- Gillies G. Department of Nuclear Engineering and Engineering Physics, University of Virginia, Charlottesville, Virginia aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 18/3(1990-05-01), 299-313 0090-6964 18:3<299 1990 18 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer