caa a22 4500 465739849 CHVBK 20180323111806.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02368442 doi (NATIONALLICENCE)springer-10.1007/BF02368442 Computer simulation of the mechanically-assisted failing canine circulation [Elektronische Daten] [Ofer Barnea, Thomas Moore, Dov Jaron] A model of the cardiovascular system is presented. The model includes representations of the left and right ventricles, a nonlinear multielement model of the aorta and its main branches, and lumped models of the systemic veins and the pulmonary circulation. A simulation of the intra-aortic balloon pump and representations of physiological compensatory mechanisms are also incorporated in the model. Parameters of the left ventricular model were set to simulate either the normal or failing canine circulation. Pressure and flow waveforms throughout the circulation as well as ventricular pressure and volume were calculated for the normal, failing, and assisted failing circulation. Cardiac oxygen supply and consumption were calculated from the model. They were used as direct indices of cardiac energy supply and utilization to assess the effects of cardiac assistance. Pergamon Press plc, 1990 Model simulation nationallicence Cardiovascular nationallicence Cardiac assist nationallicence Intra-aortic balloon nationallicence Energy balance nationallicence A m : vessel cross-sectional area atm mmHg nationallicence E : ventricular pressure-volume ratio nationallicence E max : maximum value ofE nationallicence E n : normalizedE function nationallicence E w : vessel wall elastance nationallicence P : blood pressure nationallicence P AV 0 : unperturbed mean aortic root pressure nationallicence P AV : mean aortic root pressure nationallicence P im : intramyocardial pressure nationallicence P LV : left ventricular pressure nationallicence P VL : pressure across aortic valve nationallicence P V : systemic venous blood pressure nationallicence PVA : pressure-volume area nationallicence P W : transmural pressure nationallicence Q : flow nationallicence Q LV : left ventricular flow nationallicence Q r : net flow into a vessel segment nationallicence Q VL : flow into aortic valve leaflets nationallicence r b : radius of a balloon segment nationallicence r n : radius of a vessel segment nationallicence TCF : total coronary flow per beat nationallicence t ED : time of end diastole nationallicence t ES : time of end systole nationallicence t max : time whenE equalsE max nationallicence t n : normalized time nationallicence V ED : end diastolic ventricular pressure nationallicence V Oa : oxygen availability per beat nationallicence V Oc : oxygen consumption per beat nationallicence V s : venous volume shift nationallicence V VL : aortic valve volume nationallicence η : blood viscosity nationallicence ρ : blood density nationallicence τ : time constant nationallicence Barnea Ofer Biomedical Engineering Program Department of Interdisciplinary Studies School of Engineering, Tel Aviv University, Tel Aviv, Israel aut Moore Thomas Biomedical Engineering and Science Institute, Drexel University, 19104, Philadelphia, PA aut Jaron Dov Biomedical Engineering and Science Institute, Drexel University, 19104, Philadelphia, PA aut Annals of Biomedical Engineering Kluwer Academic Publishers 18/3(1990-05-01), 263-283 0090-6964 18:3<263 1990 18 10439 https://doi.org/10.1007/BF02368442 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02368442 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barnea Ofer Biomedical Engineering Program Department of Interdisciplinary Studies School of Engineering, Tel Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Moore Thomas Biomedical Engineering and Science Institute, Drexel University, 19104, Philadelphia, PA aut NATIONALLICENCE 700 1- Jaron Dov Biomedical Engineering and Science Institute, Drexel University, 19104, Philadelphia, PA aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 18/3(1990-05-01), 263-283 0090-6964 18:3<263 1990 18 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer