caa a22 4500 465739865 CHVBK 20180323111806.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02368443 doi (NATIONALLICENCE)springer-10.1007/BF02368443 Fluorocarbon-encapsulated oxygen bubbles for blood oxygenation use: An experimental study [Elektronische Daten] [Yasuhiko Mori, Keiji Kaminaga, Takashi Ando] This paper is concerned with a novel class of oxygenators which Li and Asher first proposed and called "liquid membrane oxygenators.” They are different from usual bubble blood oxygenators in that oxygen bubbles are individually encapsulated by a liquid fluorocarbon membrane and dispersed in blood, instead of bare oxygen bubbles normally used. The fluorocarbon membrane's role is to prevent direct contact of blood with oxygen gas which can cause a rupture of red blood cells and denaturation of proteins in blood. We have attempted to produce encapsulated bubbles by use of a fine double-tube nozzle where oxygen is supplied through the inner tube of the nozzle while a liquid fluorocarbon is supplied through the annular space between the outer and the inner tubes. This device has been found to enable steady formation, both in pure water and in an queous solution of bovine serum albumin, of encapsulated bubbles of about 2 mm in diameter, which are far smaller than those produced by Li and Asher's original device. A comparative study of oxygenation of water (a substitute for blood) by encapsulated bubbles and by nonencapsulated bubbles indicates that the former is only slightly inferior to the latter. Pergamon Press plc, 1990 Blood oxygenator nationallicence Liquid membrane oxygenator nationallicence Compound drops nationallicence Compound bubbles nationallicence Mass transfer nationallicence c in : Mass fraction of oxygen in water flowing into the test column nationallicence c out : Mass fraction of oxygen in water flowing out of the test column nationallicence c sat : Mass fraction of oxygen in water in equilibrium with oxygen gas having pressure of 101.3 kPa nationallicence D : Equivalent spherical diameter of bubble nationallicence E : Fraction of oxygen transferred to water nationallicence H : Height of funnel inlet above the bottom wall of the test column nationallicence $$\dot M_G $$ : Mass flow rate of oxygen nationallicence $$\dot M_W $$ : Mass flow rate of water nationallicence n : Number of bubbles ascending in water up to heightH at each instant nationallicence U : Rise velocity of bubble nationallicence α D : Overall mass transfer coefficient for oxygen nationallicence Γ G : Volume flow rate of oxygen nationallicence Γ W : Volume flow rate of water nationallicence ν : Mass transfer efficiency for oxygen nationallicence ϕ : Ratio of volume flow rate of fluorocarbon to Γ G nationallicence Mori Yasuhiko Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, 223, Yokohama, Japan aut Kaminaga Keiji Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, 223, Yokohama, Japan aut Ando Takashi Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, 223, Yokohama, Japan aut Annals of Biomedical Engineering Kluwer Academic Publishers 18/3(1990-05-01), 285-298 0090-6964 18:3<285 1990 18 10439 https://doi.org/10.1007/BF02368443 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02368443 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mori Yasuhiko Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, 223, Yokohama, Japan aut NATIONALLICENCE 700 1- Kaminaga Keiji Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, 223, Yokohama, Japan aut NATIONALLICENCE 700 1- Ando Takashi Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, 223, Yokohama, Japan aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 18/3(1990-05-01), 285-298 0090-6964 18:3<285 1990 18 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer