caa a22 4500 465739938 CHVBK 20180323111806.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02364158 doi (NATIONALLICENCE)springer-10.1007/BF02364158 Temporal aggregate size distributions from simulation of platelet aggregation and disaggregation [Elektronische Daten] [Philip Nguyen, Edgar O'Rear] A modification of the Smoluchowski collision theory for platelet aggregation is proposed with additional kinetic terms to accommodate observed disaggregation behavior. This model, consisting of a set of coupled, nonlinear, first-order differential equations, approximates size distributions with time for normal human platelets in plasma after the addition of a stimulus. Parameters controlling the kinetics of the formation and breakup of aggregates are numerically investigated. The aggregation coefficient, predominant during the aggregation phase, is strongly dependent on both time and aggregating agent doses. For the disaggregation phase, the disaggregation rate constants are a function of aggregate size, with a time-dependent disaggregation coefficient. Numerical results generated by the model are compared with experimental volume-size distribution curves from the literature. Pergamon Press plc, 1990 Computer simulation nationallicence Platelet aggregation nationallicence Platelet disaggregation nationallicence Platelet size distributions nationallicence Nguyen Philip Department of Chemical Engineering, University of Oklahoma, T-335, 73019, Norman, OK aut O'Rear Edgar Department of Chemical Engineering, University of Oklahoma, T-335, 73019, Norman, OK aut Annals of Biomedical Engineering Kluwer Academic Publishers 18/4(1990-07-01), 427-444 0090-6964 18:4<427 1990 18 10439 https://doi.org/10.1007/BF02364158 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02364158 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nguyen Philip Department of Chemical Engineering, University of Oklahoma, T-335, 73019, Norman, OK aut NATIONALLICENCE 700 1- O'Rear Edgar Department of Chemical Engineering, University of Oklahoma, T-335, 73019, Norman, OK aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 18/4(1990-07-01), 427-444 0090-6964 18:4<427 1990 18 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer