caa a22 4500 465739946 CHVBK 20180323111806.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02364159 doi (NATIONALLICENCE)springer-10.1007/BF02364159 Analysis and prediction of left ventricular performance under load changes during cardiac catheterization [Elektronische Daten] [L. Abboud, R. Beyar, A. Battler, M. Rat, A. Cohen, S. Sideman] The applicability of a computer model, which relates the transmural mechanical distribution in the left ventricle (LV) to its global function at different loading conditions, was evaluated in patients with normal to near normal LV function undergoing cardiac catheterization. Left ventriculography and measurements of aortic and LV pressures were performed at baseline conditions and repeated following rapid volume expansion with intravenous infusion of 250 to 300 ml of physiologic saline and also after sublingual isosorbide-dinitrate (ISDN) administration. Twenty patients (18 men and 2 women, average age=53 years) underwent coronary angiography and left ventriculography. Sixteen patients had coronary artery disease with one- to three-vessel involvement and 4 had normal coronary arteries. The measured input data into the model included the end-diastolic LV volume and wall thickness, aortic pressure, heart rate, and the peripheral resistance. The model parameters of myocardial contractility and arterial system capacitance for the control baseline conditions were estimated so that an accurate match was obtained between the predicted and the measured end-systolic (ES) volume and pressure. Using these parameters, model predictions for the two load perturbations were compared to the measurements. An excellent correlation was found between the predicted and measured LV ES volumes and peak-systolic pressures (PSP) (R2>0.994). In four patients, who developed ischemic symptoms during saline injection, the prediction of end-systole volumes were lower than the measured values, suggesting an actual reduction in contractility during acute ischemia. There-fore, the model is sensitive to, contractility changes. The model predicts global LV performance, under different loading conditions, including stroke work, peak developed wall stress, velocity of fiber shortening, and myocardial oxygen consumption. Pergamon Press plc, 1990 Left ventricle nationallicence Computer model nationallicence Angiography nationallicence C : Control state nationallicence CAD : Coronary artery disease nationallicence CR : Calculated results nationallicence ED : End-diastolic nationallicence EDP : End-diastolic pressure nationallicence EDV : End-diastolic volume nationallicence EF : Ejection fraction nationallicence ES : End-systolic nationallicence ESV : End-systolic volume nationallicence ESPVR : End-systolic, pressure-volume relationship nationallicence ISDN : Isosorbide-dinitrate (IS) nationallicence LV : Left ventricle or left ventricular nationallicence M : Measured nationallicence MRI : Magnetic resonance imaging nationallicence NCA : Normal coronary arteries nationallicence NS : Normal saline infusion nationallicence PSP : Peak-systolic pressure nationallicence P-V : Pressure-volume nationallicence SL : Sarcomere lengths nationallicence Abboud L. The Rambam Medical Center, 32000, Haifa, Israel aut Beyar R. Julius Silver Institute of Biomedical Engineering Department of Biomedical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel aut Battler A. The Sheba Medical Center, Tel Hashomer, Israel aut Rat M. The Sheba Medical Center, Tel Hashomer, Israel aut Cohen A. Julius Silver Institute of Biomedical Engineering Department of Biomedical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel aut Sideman S. Julius Silver Institute of Biomedical Engineering Department of Biomedical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel aut Annals of Biomedical Engineering Kluwer Academic Publishers 18/4(1990-07-01), 445-461 0090-6964 18:4<445 1990 18 10439 https://doi.org/10.1007/BF02364159 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02364159 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abboud L. The Rambam Medical Center, 32000, Haifa, Israel aut NATIONALLICENCE 700 1- Beyar R. Julius Silver Institute of Biomedical Engineering Department of Biomedical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel aut NATIONALLICENCE 700 1- Battler A. The Sheba Medical Center, Tel Hashomer, Israel aut NATIONALLICENCE 700 1- Rat M. The Sheba Medical Center, Tel Hashomer, Israel aut NATIONALLICENCE 700 1- Cohen A. Julius Silver Institute of Biomedical Engineering Department of Biomedical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel aut NATIONALLICENCE 700 1- Sideman S. Julius Silver Institute of Biomedical Engineering Department of Biomedical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 18/4(1990-07-01), 445-461 0090-6964 18:4<445 1990 18 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer