caa a22 4500 465739954 CHVBK 20180323111806.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02364154 doi (NATIONALLICENCE)springer-10.1007/BF02364154 Parametric analysis of flow in the intramyocardial circulation [Elektronische Daten] [Rolf Holenstein, Robert Nerem] A simple mathematical model of the intramyocardial circulation has been utilized to provide a better understanding of coronary blood flow. The model includes three myocardial layers, each characterized by a three-parameter windkessel with one capacitance and two resistances. The effects of the beating heart are taken into account by means of an intramyocardial pump and the possible collapse of the vessels by an elevated backpressure. The three basic parameters that govern the flow are a normalized time constant, $$\bar \tau $$ , the total resistance, Rt, and a parameter, α, which specifies the resistance distribution in the intramyocardial circulation. Both the normal beating heart and prolonged diastole have been investigated analytically as well as numerically. It is shown that each of these parameters has its own special significance. Calculated pressure-flow relationships and zero-flow pressures for the case of prolonged diastole show a high sensitivity to $$\bar \tau $$ and α. Pergamon Press plc, 1990 Coronary circulation nationallicence Intramyocardial capacitance nationallicence Coronary pressure-flow relation nationallicence Zero-flow pressure nationallicence Holenstein Rolf Biomechanics Laboratory School of Mechanical Engineering, Georgia Institute of Technology, 30332-0405, Atlanta, GA aut Nerem Robert Biomechanics Laboratory School of Mechanical Engineering, Georgia Institute of Technology, 30332-0405, Atlanta, GA aut Annals of Biomedical Engineering Kluwer Academic Publishers 18/4(1990-07-01), 347-365 0090-6964 18:4<347 1990 18 10439 https://doi.org/10.1007/BF02364154 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02364154 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holenstein Rolf Biomechanics Laboratory School of Mechanical Engineering, Georgia Institute of Technology, 30332-0405, Atlanta, GA aut NATIONALLICENCE 700 1- Nerem Robert Biomechanics Laboratory School of Mechanical Engineering, Georgia Institute of Technology, 30332-0405, Atlanta, GA aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 18/4(1990-07-01), 347-365 0090-6964 18:4<347 1990 18 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer