caa a22 4500 465740073 CHVBK 20180323111806.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02364616 doi (NATIONALLICENCE)springer-10.1007/BF02364616 Bennett Frederick Department of Biomedical Engineering, Worcester Polytechnic Institute, 100 Institute Road, 01609, Worcester, MA aut Limitations of the open loop gain concept in studies of respiratory control [Elektronische Daten] [Frederick Bennett] A steady state mathematical model was used to study the limitations of applying the open loop gain concept to the ventilatory control system. Open loop gain is a term used in the study of linear control systems and is an indicator of how well the controlled variable is regulated. The model contained descriptions of the O2 and CO2 control systems as well as their interactions. Disturbances to the system were modelled as occurring via inspired air, metabolic rate and ventilation. The ventilatory response to hypoxia was simulated for (a) hypocapnic hypoxia, (b) normocapnic hypoxia (PaCO2=40 torr) and (c) hypercapnic hypoxia (PaCO2=45 torr). The open loop gains of the O2 and CO2 loops were calculated at each operating point. In addition, the sensitivity of the controlled variable to disturbances to the loop were also compared. It was observed that open loop gain did not completely describe the characteristics of the ventilatory control system. This was due to the fact that the ventilatory system is nonlinear and the regulatory ability of the ventilatory system depends on the route of the disturbance, and (2) open loop gain ignores the interactions of the CO2 and O2 loops, which can be substantial. Pergamon Press plc, 1990 Ventilatory control nationallicence Respiration models nationallicence Annals of Biomedical Engineering Kluwer Academic Publishers 18/5(1990-09-01), 533-547 0090-6964 18:5<533 1990 18 10439 https://doi.org/10.1007/BF02364616 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02364616 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Bennett Frederick Department of Biomedical Engineering, Worcester Polytechnic Institute, 100 Institute Road, 01609, Worcester, MA aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 18/5(1990-09-01), 533-547 0090-6964 18:5<533 1990 18 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer