caa a22 4500 465740081 CHVBK 20180323111806.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02364613 doi (NATIONALLICENCE)springer-10.1007/BF02364613 Isolated aorta setup for hemodynamic studies [Elektronische Daten] [Pieter Sipkema, Ricky Latham, Nicolaas Westerhof, Bernard Rubal, David Slife] A setup consisting of a high-performance hydraulic pump connected to the ascending part of an isolated aorta, including all major distal branches, each loaded with calibrated artificial resistors, was developed. The system was used to study total aortic compliance of the baboon as a function of mean aortic pressure (n=5). The aorta loaded with the resistors was mounted in a custom-designed sink table, such that it was submersed in physiological saline maintained at 37°C. Mean distending pressure in the entire aortic compliance from pressure and flow waves generated by the pump. Total aortic compliance as a function of mean pressure was fitted with a logarithmic function: Ln (Compliance)=A+B * P. The value of A(±SE) was: 1.565±0.319 and B: −0.020±0.003 (P<0.001). The results were compared with previously published results (also using the same three-element Windkessel fit) obtained in three of the same animalsin vivo. Thein vivo data were A: 1.095±0.235 and B: −0.019±0.003.In vitro data had a significantly higher value of A thanin vivo (P=0.017), implying a significantly higher aortic compliancein vitro thanin vivo. Occlusion of the proximal descending aorta was performed at a low distending pressure (55 mm Hg) to determine the proximal complicance. It was found (n=4) that 46±11% (SD) of the total arterial compliance is to be attributed to the ascending and proximal descending aorta. Pergamon Press plc, 1990 Isolated aorta nationallicence Compliance nationallicence Windkessel model nationallicence A, B : constants of the regression equation nationallicence P : mean distending pressure nationallicence P p : the measured perfusion pressure nationallicence F p : the measured perfusion flow nationallicence R c : the characteristic resistance nationallicence R p : the peripheral resistance nationallicence C : total arterial compliance nationallicence P x : the pressure at the compliance nationallicence F c : the flow through the compliance nationallicence F Rp : the flow through the resistance Rp nationallicence Sipkema Pieter Laboratory for Physiology Free, University of Amsterdam, P. O. Box7161, Amsterdam, The Netherlands aut Latham Ricky Cardiology Service Department of Medicine, Brooke Army Medical Center, Fort Sam, Houston, TX aut Westerhof Nicolaas Laboratory for Physiology Free, University of Amsterdam, P. O. Box7161, Amsterdam, The Netherlands aut Rubal Bernard Cardiology Service Department of Medicine, Brooke Army Medical Center, Fort Sam, Houston, TX aut Slife David Cardiology Service Department of Medicine, Brooke Army Medical Center, Fort Sam, Houston, TX aut Annals of Biomedical Engineering Kluwer Academic Publishers 18/5(1990-09-01), 491-503 0090-6964 18:5<491 1990 18 10439 https://doi.org/10.1007/BF02364613 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02364613 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sipkema Pieter Laboratory for Physiology Free, University of Amsterdam, P. O. Box7161, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Latham Ricky Cardiology Service Department of Medicine, Brooke Army Medical Center, Fort Sam, Houston, TX aut NATIONALLICENCE 700 1- Westerhof Nicolaas Laboratory for Physiology Free, University of Amsterdam, P. O. Box7161, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Rubal Bernard Cardiology Service Department of Medicine, Brooke Army Medical Center, Fort Sam, Houston, TX aut NATIONALLICENCE 700 1- Slife David Cardiology Service Department of Medicine, Brooke Army Medical Center, Fort Sam, Houston, TX aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 18/5(1990-09-01), 491-503 0090-6964 18:5<491 1990 18 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer