caa a22 4500 465740227 CHVBK 20180323111807.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02368428 doi (NATIONALLICENCE)springer-10.1007/BF02368428 Using fractals to understand the opening and closing of ion channels [Elektronische Daten] [Larry Liebovitch, Tibor Tóth] Looking at an old problem from a new perspective can sometimes lead to new ways of analyzing experimental data which may help in understanding the mechanisms that underlie the phenomena. We show how the application of fractals to analyze the patch clamp recordings of the sequence of open and closed times of cell membrane ion channels has led to a new description of ion channel kinetics. This new information has led to new models that imply: (a) ion channel proteins have many conformational states of nearly equal energy minima and many pathways connecting one conformational state to another, and (b) that these many states are not independent but are linked by physical mechanisms that result in the observed fractal scaling. The first result is consistent with many experiments, simulations, and theories of globular proteins developed over the last decade. The second result has stimulated the suggestion of several different physical mechanisms that could cause the fractal scalings observed. Pergamon Press plc, 1990 Liebovitch Larry Department of Ophthalmology College of Physicians and Surgeons, Columbia University, 630 West 168th St., 10032, New York, NY aut Tóth Tibor Department of Ophthalmology College of Physicians and Surgeons, Columbia University, 630 West 168th St., 10032, New York, NY aut Annals of Biomedical Engineering Kluwer Academic Publishers 18/2(1990-03-01), 177-194 0090-6964 18:2<177 1990 18 10439 https://doi.org/10.1007/BF02368428 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02368428 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liebovitch Larry Department of Ophthalmology College of Physicians and Surgeons, Columbia University, 630 West 168th St., 10032, New York, NY aut NATIONALLICENCE 700 1- Tóth Tibor Department of Ophthalmology College of Physicians and Surgeons, Columbia University, 630 West 168th St., 10032, New York, NY aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 18/2(1990-03-01), 177-194 0090-6964 18:2<177 1990 18 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer