caa a22 4500 465742726 CHVBK 20180323111812.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF02021554 doi (NATIONALLICENCE)springer-10.1007/BF02021554 Effects of short chain fatty acids and K on absorption of Mg and other cations by the colon and caecum [Elektronische Daten] [E. Scharrer, T. Lutz] Summary: The influence of short chain fatty acids (SCFA) on Mg, Na, and water absorption was studied in the rat distal colon and caecum using an in vivo luminal perfusion technique. The effect of SCFA on K absorption by the distal colon and the effect of K on Mg absorption by the distal colon and caecum were also investigated. Butyrate (60 mmol/l) or a mixture of SCFA (60 mmol/l acetate, 20 mmol/l propionate, 10 mmol/l butyrate) stimulated Mg and K absorption by the distal colon, while Na and water absorption was not affected. The effect on Mg absorption was pH-dependent. In the caecum, butyrate enhanced Na and water absorption, but not Mg absorption. Acetate (60 mmol/l) did not influence electrolyte absorption by either intestinal segment. K (30 mmol/l) inhibited Mg absorption by the distal colon, but not by the caecum. It is concluded from these findings that SCFA deriving from fermentation of carbohydrates in the large intestine stimulate Mg, K, and Na absorption by delivering protons to Mg++/H+, K+/H+ and Na+/H+ exchangers located in the apical membrane of the epithelium. K seems to inhibit Mg absorption in the colon by affecting a mechanism which does not respond to SCFA. Dr. Dietrich Steinkopff Verlag, 1990 Mg absorption nationallicence Na absorption nationallicence K absorption nationallicence short chain fatty acids nationallicence colon nationallicence caecum nationallicence Mg-Absorption nationallicence Na-Absorption nationallicence K-Absorption nationallicence kurzkettige Fettsäuren nationallicence Kolon nationallicence Zäkum nationallicence SCFA : Short chain fatty acids nationallicence Scharrer E. Institut für Veterinär-Physiologie, Universität Zürich, Schweiz aut Lutz T. Institut für Veterinär-Physiologie, Universität Zürich, Schweiz aut Zeitschrift für Ernährungswissenschaft Steinkopff-Verlag 29/3(1990-09-01), 162-168 0044-264X 29:3<162 1990 29 394 https://doi.org/10.1007/BF02021554 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02021554 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Scharrer E. Institut für Veterinär-Physiologie, Universität Zürich, Schweiz aut NATIONALLICENCE 700 1- Lutz T. Institut für Veterinär-Physiologie, Universität Zürich, Schweiz aut NATIONALLICENCE 773 0- Zeitschrift für Ernährungswissenschaft Steinkopff-Verlag 29/3(1990-09-01), 162-168 0044-264X 29:3<162 1990 29 394 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer