caa a22 4500 465743315 CHVBK 20180323111813.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02707179 doi (NATIONALLICENCE)springer-10.1007/BF02707179 Choi Jeong-Woo Department of Chemical and Biochemical Engineering, Rutgers, The Stale University of New Jersey, 08855, New Brunswick, NJ aut Bioproduct adsorption in immobilized adsorbent: Local thermodynamic equilibrium model [Elektronische Daten] [Jeong-Woo Choi] A mathematical model using local thermodynamic equilibrium isotherms for adsorption on immobilized adsorbents is proposed in order to optimize the design parameters inin situ bioproduct separation process. The model accurately follows the experimental data on the adsorption of berberine, secondary metabolite produced in plant cell culture. The result shows that the lower loading capacity in immobilized adsorbents is due to the decrease in the maximum solid phase concentration and the isotherm equilibrium constant, not the effective diffusivity. Design parameters inin situ bioproduct separation process, such as the size of the beads, the ratio of beads to bulk volume and the adsorbent content of the bead, are evaluated by using the model. The decrease of bead size is the most effective parameter for adsorption of berberine in immobilized adsorbent due to a reduction in the overall diffusional resistance. Korean Institute of Chemical Engineering, 1990 Korean Journal of Chemical Engineering Springer-Verlag 7/4(1990-10-01), 269-278 0256-1115 7:4<269 1990 7 11814 https://doi.org/10.1007/BF02707179 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02707179 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Choi Jeong-Woo Department of Chemical and Biochemical Engineering, Rutgers, The Stale University of New Jersey, 08855, New Brunswick, NJ aut NATIONALLICENCE 773 0- Korean Journal of Chemical Engineering Springer-Verlag 7/4(1990-10-01), 269-278 0256-1115 7:4<269 1990 7 11814 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer