caa a22 4500 465744567 CHVBK 20180323111817.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02239835 doi (NATIONALLICENCE)springer-10.1007/BF02239835 Elimination of Theileria buffeli infections from cattle by concurrent treatment with primaquine phosphate and halofuginone lactate [Elektronische Daten] [N. Stewart, A. de Vos, I. Shiels] Elimination d'Infections A Theileria Buffeli Chez Des Bovins Par Traitement Simultane Avec Du Phosphate De Primaquine Et Du Lactate d'Halofuginone Summary: Fifty splenectomised calves naturally infected withTheileria buffeli were treated with primaquine phosphate (ICI, UK) and halofuginone lactate (Hoechst, Australia) either separately or in combination. Infections in treated calves were monitored for up to 26 weeks by examining Giemsa stained peripheral blood films for piroplasms and by an immunofluorescent antibody test. When used alone neither of the drugs eliminated infection. The most successful results were obtained when two treatments of halofuginone lactate, at a rate of 1 mg kg−1 body weight and six treatments of primaquine phosphate, at a rate of 2 mg kg−1 body weight, were administered concurrently. No theilerial relapses were observed in 14 of 16 calves so treated, and no antibody toT. buffeli was detected in these calves beyond the twelfth week after treatment. The results have application in the preparation ofTheileria-free calves for use in the production of living vaccines against babesiosis and anaplasmosis. Centre for Tropical Veterinary Medicine, 1990 Stewart N. Queensland Department of Primary Industries, Animal Research Institute, Tick Fever Research Centre, 4076, Wacol, Queensland, Australia aut de Vos A. Queensland Department of Primary Industries, Animal Research Institute, Tick Fever Research Centre, 4076, Wacol, Queensland, Australia aut Shiels I. Queensland Department of Primary Industries, Animal Research Institute, Tick Fever Research Centre, 4076, Wacol, Queensland, Australia aut Tropical Animal Health and Production Kluwer Academic Publishers-Human Sciences Press 22/2(1990-06-01), 109-115 0049-4747 22:2<109 1990 22 11250 https://doi.org/10.1007/BF02239835 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02239835 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stewart N. Queensland Department of Primary Industries, Animal Research Institute, Tick Fever Research Centre, 4076, Wacol, Queensland, Australia aut NATIONALLICENCE 700 1- de Vos A. Queensland Department of Primary Industries, Animal Research Institute, Tick Fever Research Centre, 4076, Wacol, Queensland, Australia aut NATIONALLICENCE 700 1- Shiels I. Queensland Department of Primary Industries, Animal Research Institute, Tick Fever Research Centre, 4076, Wacol, Queensland, Australia aut NATIONALLICENCE 773 0- Tropical Animal Health and Production Kluwer Academic Publishers-Human Sciences Press 22/2(1990-06-01), 109-115 0049-4747 22:2<109 1990 22 11250 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer