caa a22 4500 465745105 CHVBK 20180323111818.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF01808280 doi (NATIONALLICENCE)springer-10.1007/BF01808280 Different effects of eubacterial and eukaryotic DNA topoisomerase II inhibitors on chloroplasts of Euglena gracilis [Elektronische Daten] [Juraj Krajčovič, Libor Ebringer] Inhibitors of eubacterial and eukaryotic DNA topoisomerases type II exhibited different effects on chloroplasts of the flagellateEuglena gracilis. Antibacterial agents (cinoxacin, nalidixic and oxolinic acids, ciprofloxacin, enoxacin, norfloxacin and ofloxacin) from the group of quinolones and coumarins (coumermycin A1, clorobiocin and novobiocin) — all inhibitors of prokaryotic DNA topoisomerase II — were very potent eliminators of chloroplasts fromE. gracilis. In contrast, antitumor drugs (adriamycin, etoposide, teniposide and mitoxantrone) — antagonists of the eukaryotic counterpart — did not affect these semiautonomous photosynthetic organelles. These findings point out again the close evolutionary relationships between eubacteria and chloroplasts and are in agreement with the hypothesis of an endosymbiotic origin of chloroplasts. Kluwer Academic Publishers, 1990 Krajčovič Juraj Institute of Molecular and Subcellular Biology, Comenius University, 811 07, Bratislava, Czechoslovakia aut Ebringer Libor Institute of Molecular and Subcellular Biology, Comenius University, 811 07, Bratislava, Czechoslovakia aut Origins of life and evolution of the biosphere Kluwer Academic Publishers 20/2(1990-03-01), 177-180 0169-6149 20:2<177 1990 20 11084 https://doi.org/10.1007/BF01808280 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01808280 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Krajčovič Juraj Institute of Molecular and Subcellular Biology, Comenius University, 811 07, Bratislava, Czechoslovakia aut NATIONALLICENCE 700 1- Ebringer Libor Institute of Molecular and Subcellular Biology, Comenius University, 811 07, Bratislava, Czechoslovakia aut NATIONALLICENCE 773 0- Origins of life and evolution of the biosphere Kluwer Academic Publishers 20/2(1990-03-01), 177-180 0169-6149 20:2<177 1990 20 11084 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer