caa a22 4500 465745156 CHVBK 20180323111818.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF01808276 doi (NATIONALLICENCE)springer-10.1007/BF01808276 Template-directed oligomerization of 5′-deoxy-5′-nucleosideacetic acid derivatives [Elektronische Daten] [Kazuo Harada, Leslie Orgel] 5′-Deoxy-5′-nucleosideacetic acids II-V are isostructural analogues of nucleotides with a carboxylate group in the place of the 5′-phosphate group. We have studied their oligomerization in aqueous solution using a water-soluble carbodiimide as the condensing agent in the presence or absence of an appropriate polynucleotide template. Condensation of adenylic acid analogues IIa, IIIa, and Va in the presence of polyuridylic acid were found to be the most efficient reactions. Cyclization of the activated monomers to lactones and the insolubility of the oligomers in aqueous solution were found to be obstacles to the efficient formation of long oligomers. Kluwer Academic Publishers, 1990 Harada Kazuo The Salk Institute for Biological Studies, Post Office Box 85800, 92138, San Diego, CA, USA aut Orgel Leslie The Salk Institute for Biological Studies, Post Office Box 85800, 92138, San Diego, CA, USA aut Origins of life and evolution of the biosphere Kluwer Academic Publishers 20/2(1990-03-01), 151-160 0169-6149 20:2<151 1990 20 11084 https://doi.org/10.1007/BF01808276 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01808276 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Harada Kazuo The Salk Institute for Biological Studies, Post Office Box 85800, 92138, San Diego, CA, USA aut NATIONALLICENCE 700 1- Orgel Leslie The Salk Institute for Biological Studies, Post Office Box 85800, 92138, San Diego, CA, USA aut NATIONALLICENCE 773 0- Origins of life and evolution of the biosphere Kluwer Academic Publishers 20/2(1990-03-01), 151-160 0169-6149 20:2<151 1990 20 11084 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer