caa a22 4500 465745199 CHVBK 20180323111818.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02624718 doi (NATIONALLICENCE)springer-10.1007/BF02624718 Comparative study of the therapeutic effects of glibenclamide or the fixed combination of glibenclamide-phenformin with those of gliclazide or chlorpropamide [Elektronische Daten] [Athanasios Raptis, Nickolaos Tountas, Athanasios Yalouris, Dimitrios Hadjidakis, Ariadne Zaharis, Konstantinos Miras, Sotos Raptis] Summary: This study was designed to compare the therapeutic effects of glibenclamide or the fixed combination of glibenclamide-phenformin with those of gliclazide, chlorpropamide or biguanides in non-insulin-dependent diabetes. It is divided into two parts: a) in the retrospective study (473 subjects), glucose control of patients who were transferred from chlorpropamide, gliclazide, glibenclamide, glibenclamide + biguanide or metformin to the fixed combination glibenclamide-phenformin in the same tablet (2.5 mg and 25 mg, respectively) was monitored. A statistically significant decrease of blood glucose and glycosylated hemoglobin values was found under the combination of glibenclamide-phenformin contained in the same tablet in contrast to the values obtained with the treatment with glibenclamide, gliclazide, chlorpropamide, combination of glibenclamide and biguanides, metformin, and insulin. b) In the prospective study (57 subjects), the patients were transferred from chlorpropamide or gliclazide to glibenclamide for 3 months and then reallocated to the previous treatment for 3 additional months. It was found that under glibenclamide, glucose control was significantly better than under chlorpropamide or gliclazide. In conclusion, glibenclamide, a second generation sulfonylurea, and the fixed combination glibenclamide-phenformin in the same tablet are more effective compared to the other antidiabetic agents here studied and lead to a better control of type II diabetic patients. There was no increase in plasma lactic acid concentration in all patients studied before and after having received the fixed combination of glibenclamide-phenformin in the single tablet form. Casa Editrice «il Ponte», 1990 Antidiabetic tablets nationallicence Biguanides nationallicence Diabetes mellitus nationallicence Diabetic micro- and macroangiopathy nationallicence Sulfonylureas nationallicence Raptis Athanasios Second Department of Internal Medicine-Propaedeutic, Athens University, Evangelismos Hospital, Athens aut Tountas Nickolaos Second Department of Internal Medicine-Propaedeutic, Athens University, Evangelismos Hospital, Athens aut Yalouris Athanasios Second Department of Internal Medicine-Propaedeutic, Athens University, Evangelismos Hospital, Athens aut Hadjidakis Dimitrios Second Department of Internal Medicine-Propaedeutic, Athens University, Evangelismos Hospital, Athens aut Zaharis Ariadne Department of Biological Chemistry, Athens University, Athens, Greece aut Miras Konstantinos Department of Biological Chemistry, Athens University, Athens, Greece aut Raptis Sotos Second Department of Internal Medicine-Propaedeutic, Athens University, Evangelismos Hospital, Athens aut Acta diabetologia latina Springer-Verlag 27/1(1990-03-01), 11-22 0001-5563 27:1<11 1990 27 592 https://doi.org/10.1007/BF02624718 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02624718 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raptis Athanasios Second Department of Internal Medicine-Propaedeutic, Athens University, Evangelismos Hospital, Athens aut NATIONALLICENCE 700 1- Tountas Nickolaos Second Department of Internal Medicine-Propaedeutic, Athens University, Evangelismos Hospital, Athens aut NATIONALLICENCE 700 1- Yalouris Athanasios Second Department of Internal Medicine-Propaedeutic, Athens University, Evangelismos Hospital, Athens aut NATIONALLICENCE 700 1- Hadjidakis Dimitrios Second Department of Internal Medicine-Propaedeutic, Athens University, Evangelismos Hospital, Athens aut NATIONALLICENCE 700 1- Zaharis Ariadne Department of Biological Chemistry, Athens University, Athens, Greece aut NATIONALLICENCE 700 1- Miras Konstantinos Department of Biological Chemistry, Athens University, Athens, Greece aut NATIONALLICENCE 700 1- Raptis Sotos Second Department of Internal Medicine-Propaedeutic, Athens University, Evangelismos Hospital, Athens aut NATIONALLICENCE 773 0- Acta diabetologia latina Springer-Verlag 27/1(1990-03-01), 11-22 0001-5563 27:1<11 1990 27 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer