caa a22 4500 465745318 CHVBK 20180323111819.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02581336 doi (NATIONALLICENCE)springer-10.1007/BF02581336 Medial arterial calcification and diabetic neuropathy [Elektronische Daten] [Sandro Gentile, Antonio Bizzarro, Riccardo Marmo, Annamaria de Bellis, Cosimo Orlando] Summary: The aim of this study was to detect linear arterial calcification (Mönckeberg's sclerosis) localized in feet, ankles, legs, knees and hands in an attempt to correlate the extent of calcification with the presence and severity of autonomic neuropathy as well as with microangiopathy (proliferative retinopathy, proteinuria >200 mg/die) and peripheral neuropathy. Typical linear calcification were observed in 37 out of 41 (90.2%) patients with autonomic neuropathy and in none of those without autonomic neuropathy (p<0.001). These 37 patients were divided into two subgroups by cluster analysis: Subgroup A, including 18 subjects with calcification length ranging from 8 to 26 cm and moderate autonomic neuropathy, and Subgroup B, including 19 subjects with calcification length between 58 and 126 cm and severe autonomic neuropathy (p<0.0001 by Spearman's test). No difference in the length of arterial calcification was detected between patients with proteinuria >200 mg/24h and/or proliferative retinopathy and patients without these complications. A possible relationship between arterial calcification and peripheral neuropathy is difficult to evaluate; in fact, the majority of subjects having autonomic neuropathy had peripheral neuropathy, too. Vice versa, around 10% of patients without peripheral neuropathy but with autonomic neuropathy did not have Mönckeberg's sclerosis. Autonomic neuropathy is the principal factor responsible for calcification of the arterial media, and in addition the severity of the neuropathy, rather than the patient's age or the known disease duration seems to determine the extent of calcification. Casa Editrice il Ponte, 1990 Autonomic neuropathy nationallicence Mönckenberg's sclerosis nationallicence Gentile Sandro Istituto di Medicina Generale e Metodologia Clinica, I Facoltà di Medicina, Università di Napoli, Napoli aut Bizzarro Antonio Cattedra di Patologia Speciale Medica e Metodologia Clinica, I Facoltà di Medicina, Università di Napoli, Napoli, Italy aut Marmo Riccardo Istituto di Medicina Generale e Metodologia Clinica, I Facoltà di Medicina, Università di Napoli, Napoli aut de Bellis Annamaria Cattedra di Patologia Speciale Medica e Metodologia Clinica, I Facoltà di Medicina, Università di Napoli, Napoli, Italy aut Orlando Cosimo Istituto di Medicina Generale e Metodologia Clinica, I Facoltà di Medicina, Università di Napoli, Napoli aut Acta diabetologia latina Springer-Verlag 27/3(1990-07-01), 243-253 0001-5563 27:3<243 1990 27 592 https://doi.org/10.1007/BF02581336 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02581336 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gentile Sandro Istituto di Medicina Generale e Metodologia Clinica, I Facoltà di Medicina, Università di Napoli, Napoli aut NATIONALLICENCE 700 1- Bizzarro Antonio Cattedra di Patologia Speciale Medica e Metodologia Clinica, I Facoltà di Medicina, Università di Napoli, Napoli, Italy aut NATIONALLICENCE 700 1- Marmo Riccardo Istituto di Medicina Generale e Metodologia Clinica, I Facoltà di Medicina, Università di Napoli, Napoli aut NATIONALLICENCE 700 1- de Bellis Annamaria Cattedra di Patologia Speciale Medica e Metodologia Clinica, I Facoltà di Medicina, Università di Napoli, Napoli, Italy aut NATIONALLICENCE 700 1- Orlando Cosimo Istituto di Medicina Generale e Metodologia Clinica, I Facoltà di Medicina, Università di Napoli, Napoli aut NATIONALLICENCE 773 0- Acta diabetologia latina Springer-Verlag 27/3(1990-07-01), 243-253 0001-5563 27:3<243 1990 27 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer