caa a22 4500 465745350 CHVBK 20180323111819.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02581333 doi (NATIONALLICENCE)springer-10.1007/BF02581333 HLA antigens in spanish type 1 diabetic population. correlations with clinical, biological and autoimmune markers [Elektronische Daten] [Albert Goday, Eduard Motaña, Guadalupe Ercilla, Josefa Fernandez, Ramon Gomis, Enric Vilardell] Summary: The HLA haplotype and its relationships with clinical, biological and immunological parameters were analyzed in a group of 87 Spanish type I diabetic patients at the clinical onset of the disease. The frequency of HLA-B18, DR3 and DR4 antigens was significantly increased whereas DR2, DR5 and DR7 were decreased in comparison with 189 healthy unrelated controls without family history of diabetes. DR3 showed a maximum relative risk for diabetes (5.5) whereas DR4 had a lower one (4.0). HLA-DR4 patients were younger at the time of diagnosis than DR4 negative (16.7vs 21.4 years). We found no statistically significant relationship between HLA antigens and the other variables studied including the presence of islet cell antibodies, complement fixing islet cell antibodies, insulin autoantibodies, organ-specific antibodies, fasting and maximal glucagon stimulated C-peptide levels, initial glycemia and glycosylated hemoglobin. Casa Editrice il Ponte, 1990 Autoimmunity nationallicence HLA nationallicence ICA nationallicence Type 1 diabetes nationallicence Goday Albert Servei d'Endocrinologia i diabetis, Hospital Clinic, Villarroeal 170, 08036, Barcelona, Spain aut Motaña Eduard Hospital Principes de España de Bellvitge, Barcelona aut Ercilla Guadalupe Servei d'Immunologia Hospital Clinic, Barcelona, Spain aut Fernandez Josefa Servei d'Endocrinologia i diabetis, Hospital Clinic, Villarroeal 170, 08036, Barcelona, Spain aut Gomis Ramon Servei d'Endocrinologia i diabetis, Hospital Clinic, Villarroeal 170, 08036, Barcelona, Spain aut Vilardell Enric Servei d'Endocrinologia i diabetis, Hospital Clinic, Villarroeal 170, 08036, Barcelona, Spain aut Acta diabetologia latina Springer-Verlag 27/3(1990-07-01), 215-222 0001-5563 27:3<215 1990 27 592 https://doi.org/10.1007/BF02581333 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02581333 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goday Albert Servei d'Endocrinologia i diabetis, Hospital Clinic, Villarroeal 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Motaña Eduard Hospital Principes de España de Bellvitge, Barcelona aut NATIONALLICENCE 700 1- Ercilla Guadalupe Servei d'Immunologia Hospital Clinic, Barcelona, Spain aut NATIONALLICENCE 700 1- Fernandez Josefa Servei d'Endocrinologia i diabetis, Hospital Clinic, Villarroeal 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Gomis Ramon Servei d'Endocrinologia i diabetis, Hospital Clinic, Villarroeal 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Vilardell Enric Servei d'Endocrinologia i diabetis, Hospital Clinic, Villarroeal 170, 08036, Barcelona, Spain aut NATIONALLICENCE 773 0- Acta diabetologia latina Springer-Verlag 27/3(1990-07-01), 215-222 0001-5563 27:3<215 1990 27 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer