caa a22 4500 465745369 CHVBK 20180323111819.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02581334 doi (NATIONALLICENCE)springer-10.1007/BF02581334 HLA gene and phenotype data of 60 insulin-dependent diabetic patients from north-eastern Italy. A negative association with DR5 rather than DR2? [Elektronische Daten] [Claudio Maffeis, Stefano Ciaffoni, Enrico Gonfiatini, Claudia Roata, Leonardo Pinelli] Summary: The purpose of our study was to evaluate what kind of relationships exist between HLA antigens and insulin-dependent diabetes mellitus (IDDM), in 20 families and in 40 single patients coming from and living in North Eastern Italy. The subjects studied show a strong association with HLA-DR3 and/or -DR4; at least one of these antigens is present in 88% of the diabetic subjects; this confirms that these antigens play a role in the pathogenesis of IDDM. We also noticed a negative association between IDDM and DR5 rather than DR2 and DR7. This result supports the hypothesis of a specific protective effect of DR5, at least as regards the population studied. Possibly, the gene(s) hypothetically involved in the protection against IDDM is (are) in linkage disequilibrium with DR2 and/or DR7 in some Caucasian populations and with DR5 in others. Another important result is the frequent HLA identity (75% of cases) among diabetic siblings of the same families. This result indicates that HLA identity is the main condition respondible for the susceptibility to the disease in the healthy siblings with HLA antigens identical to the diabetic siblings. Casa Editrice il Ponte, 1990 Genetics nationallicence HLA nationallicence Type 1 diabetes nationallicence Maffeis Claudio Centro Regionale per il Diabete Giovanile, Clinica Pediatrica, Università degli Studi di Verona, Verona aut Ciaffoni Stefano Servizio Trasfusionale e di Immunoematologia, Ospedale Civile Maggiore, Verona, Italy aut Gonfiatini Enrico Centro Regionale per il Diabete Giovanile, Clinica Pediatrica, Università degli Studi di Verona, Verona aut Roata Claudia Servizio Trasfusionale e di Immunoematologia, Ospedale Civile Maggiore, Verona, Italy aut Pinelli Leonardo Centro Regionale per il Diabete Giovanile, Clinica Pediatrica, Università degli Studi di Verona, Verona aut Acta diabetologia latina Springer-Verlag 27/3(1990-07-01), 223-230 0001-5563 27:3<223 1990 27 592 https://doi.org/10.1007/BF02581334 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02581334 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maffeis Claudio Centro Regionale per il Diabete Giovanile, Clinica Pediatrica, Università degli Studi di Verona, Verona aut NATIONALLICENCE 700 1- Ciaffoni Stefano Servizio Trasfusionale e di Immunoematologia, Ospedale Civile Maggiore, Verona, Italy aut NATIONALLICENCE 700 1- Gonfiatini Enrico Centro Regionale per il Diabete Giovanile, Clinica Pediatrica, Università degli Studi di Verona, Verona aut NATIONALLICENCE 700 1- Roata Claudia Servizio Trasfusionale e di Immunoematologia, Ospedale Civile Maggiore, Verona, Italy aut NATIONALLICENCE 700 1- Pinelli Leonardo Centro Regionale per il Diabete Giovanile, Clinica Pediatrica, Università degli Studi di Verona, Verona aut NATIONALLICENCE 773 0- Acta diabetologia latina Springer-Verlag 27/3(1990-07-01), 223-230 0001-5563 27:3<223 1990 27 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer