caa a22 4500 465745458 CHVBK 20180323111819.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02580933 doi (NATIONALLICENCE)springer-10.1007/BF02580933 QT interval prolongation in type 2 (non-insulin-dependent) diabetic patients with cardiac autonomic neuropathy [Elektronische Daten] [György Jermendy, Mária Koltai, Gábor Pogátsa] Summary: QT interval alterations were measured in 41 non-insulin-dependent (type 2) diabetic patients and 14 age- and sex-matched control subjects. Cardiac autonomic neuropathy (CAN) was assessed by noninvasive tests (deep breathing, Valsalva maneuver and lying-to-standing) and diabetics were divided into three groups according to the results of these tests: diabetics with definitive (n=14), early (n=13) and without (n=14) CAN. The corrected values of QT intervals (QTc) at rest were significantly longer in diabetics with definitive (447±5 ms; p<0.001), early (426±5 ms; p<0.05) and without (424±5 ms; p<0.05) CAN than in controls (407±5 ms). Moreover, QTc intervals at rest were significantly (p<0.01) longer in diabetics with definitive CAN than in diabetics with early and without CAN. QTc intervals at maximum tachycardia, induced by Valsalva maneuver, were considerably longer in diabetics with definitive CAN (451±6 ms) than in controls (407±6 ms; p<0.001) and in diabetics with early (434±6 ms; p<0.05) or without (422±6 ms; p<0.01) CAN. Furthermore, QTc intervals at maximum tachycardia were significantly (p<0.01) longer in diabetics with early CAN than in controls. QTc intervals at maximum bradycardia after Valsalva maneuver were significantly longer in diabetics with definitive (446±5 ms; p<0.001), early (434±5 ms; p<0.001) and without (424±5 ms; p<0.01) CAN than in controls (403±5 ms). Moreover, QTc intervals at maximum bradycardia were considerably (p<0.01) longer in diabetics with definitive than without CAN. At least one abnormal (>440 ms) QTc period was found in 19 out of 27 patients with early or definitive CAN, but 4 of 14 diabetics without any signs of CAN and none of the controls exibited abnormal QTc period. It was concluded that QTc interval prolongation due to imbalance of autonomic nervous tone could be observed in type 2 diabetic patients with CAN, suggesting a possible role in sudden cardiac death. Casa Editrice «il Ponte», 1990 Autonomic neuropathy nationallicence Diabetes mellitus nationallicence Electrical systole nationallicence QT interval nationallicence Sudden cardiac death nationallicence Type 2 diabetes nationallicence Jermendy György Merényi Kórház Belgyógyászati Osztály, Gyáli ut 17-19, 1097, Budapest, Hungary aut Koltai Mária Országos Kardiológiai Intézet Kutatási Osztály, Budapest, Hungary aut Pogátsa Gábor Országos Kardiológiai Intézet Kutatási Osztály, Budapest, Hungary aut Acta diabetologia latina Springer-Verlag 27/4(1990-10-01), 295-301 0001-5563 27:4<295 1990 27 592 https://doi.org/10.1007/BF02580933 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02580933 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jermendy György Merényi Kórház Belgyógyászati Osztály, Gyáli ut 17-19, 1097, Budapest, Hungary aut NATIONALLICENCE 700 1- Koltai Mária Országos Kardiológiai Intézet Kutatási Osztály, Budapest, Hungary aut NATIONALLICENCE 700 1- Pogátsa Gábor Országos Kardiológiai Intézet Kutatási Osztály, Budapest, Hungary aut NATIONALLICENCE 773 0- Acta diabetologia latina Springer-Verlag 27/4(1990-10-01), 295-301 0001-5563 27:4<295 1990 27 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer