caa a22 4500 465745490 CHVBK 20180323111819.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02580935 doi (NATIONALLICENCE)springer-10.1007/BF02580935 Plasma concentrations of glucagon during hyperglycemic clamp with or without somatostatin infusion in obese subjects [Elektronische Daten] [Enzo Bonora, Paolo Moghetti, Vittorio Cacciatori, Marina Zenere, Flavia Tosi, Daniela Travia, Giacomo Zoppini, Laura Perobelli, Michele Muggeo] Summary: The aim of the present study was to evaluate whether the inhibitory effect on pancreatic A-cell exerted by hyperglycemic hyperinsulinemia and/or by somatostatin administration is impaired in human obesity. For this purpose plasma glucagon concentrations were measured in 8 obese and 8 nonobese nondiabetic subjects during a 4-h hyperglycemic clamp. Synthetic cyclic somatostatin-14 was infused at the rate of 2.5 nmol/min during the third hour of the study. Fasting plasma glucagon was higher in obese than in nonobese subjects (242±32vs 163±15 pg/ml, p<0.05) (mean±SEM). In the last 20 min of the glucose infusion period preceding somatostatin administration (100-120 min of the study) plasma glucagon averaged 195±26 pg/ml in obese and 122±13 pg/ml in nonobese subjects (p<0.05), with a reduction of 19±3% in the former and 28±4% in the latter (p=n.s.). In both groups somatostatin infusion did not result in a further decrease in plasma glucagon, which averaged 192±27 pg/ml in obese and 123±16 pg/ml in nonobese subjects (p<0.05) in the 160-180 min period of the study. Also after discontinuing somatostatin infusion plasma glucagon levels did not change. These results suggest that in human obesity hyperglycemic hyperinsulinemia has a normal inhibitory effect on pancreatic A-cell and that somatostatin administration has no additive effect on hyperglycemia and hyperinsulinemia in either obese or nonobese nondiabetic subjects. Casa Editrice «il Ponte», 1990 Glucagon nationallicence Hyperglycemia nationallicence Insulin nationallicence Obesity nationallicence Somatostatin nationallicence Bonora Enzo Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut Moghetti Paolo Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut Cacciatori Vittorio Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut Zenere Marina Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut Tosi Flavia Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut Travia Daniela Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut Zoppini Giacomo Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut Perobelli Laura Laboratorio di Chimica Clinica ed Ematologia, Ospedale Maggiore di Verona, Verona, Italy aut Muggeo Michele Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut Acta diabetologia latina Springer-Verlag 27/4(1990-10-01), 309-314 0001-5563 27:4<309 1990 27 592 https://doi.org/10.1007/BF02580935 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02580935 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bonora Enzo Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut NATIONALLICENCE 700 1- Moghetti Paolo Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut NATIONALLICENCE 700 1- Cacciatori Vittorio Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut NATIONALLICENCE 700 1- Zenere Marina Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut NATIONALLICENCE 700 1- Tosi Flavia Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut NATIONALLICENCE 700 1- Travia Daniela Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut NATIONALLICENCE 700 1- Zoppini Giacomo Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut NATIONALLICENCE 700 1- Perobelli Laura Laboratorio di Chimica Clinica ed Ematologia, Ospedale Maggiore di Verona, Verona, Italy aut NATIONALLICENCE 700 1- Muggeo Michele Cattedra di Malattie del Metabolismo, Università di Verona Ospedale Policlinico, I-37134, Verona, Italy aut NATIONALLICENCE 773 0- Acta diabetologia latina Springer-Verlag 27/4(1990-10-01), 309-314 0001-5563 27:4<309 1990 27 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer