caa a22 4500 465745512 CHVBK 20180323111819.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02580938 doi (NATIONALLICENCE)springer-10.1007/BF02580938 Plasma renin activity and urinary kallikrein excretion in response to intravenous furosemide in diabetic patients [Elektronische Daten] [Shyam Lall, Shanti Kunchaparty, Hefazat Siddiqui, Jasbir Bajaj] Summary: The responsiveness of renin-angiotensin and kallikrein-kinin systems to furosemide challenge has been investigated in forty-six diabetic patients (34 NIDDM/12 IDDM), subdivided into Group I (uncomplicated DM), Group II (DM with hypertension), Group III (DM with nephropathy), Group IV (DM with hypertension and nephropathy) and a control group of 10 healthy volunteers. Plasma renin activity (PRA) was estimated by radioimmunoassay in blood samples drawn before and 10 min after furosemide administration (0.5 mg/kg i.v.). Urinary kallikrein levels were measured by bioassay using estrogenized rat uterus preparation in 4h urine samples collected before and after the diuretic. Urinary Na+ and K+ were also measured. The basal PRA in diabetics was not significantly different from controls, whereas, urinary kallikrein levels were markedly low in all patients. Both PRA and kallikrein levels increased after furosemide in controls while in diabetics this response was severely blunted. In a subset of Group I, a paradoxical fall in PRA and kallikrein levels was noted after furosemide, an effect similar to that observed in patients with nephropathy (Group III). This response in absence of clinical and biochemical parameters of nephropathy indicates early derangement of renal hemodynamic mechanisms heralding the onset of nephropathy. Casa Editrice «il Ponte», 1990 Diabetic nephropathy nationallicence Furosemide nationallicence Plasma renin activity nationallicence Urinary kallikrein nationallicence Lall Shyam Department of Pharmacology, All-India Institute of Medical Sciences, 110 029, New Delhi, India aut Kunchaparty Shanti Department of Pharmacology, All-India Institute of Medical Sciences, 110 029, New Delhi, India aut Siddiqui Hefazat Department of Pharmacology, All-India Institute of Medical Sciences, 110 029, New Delhi, India aut Bajaj Jasbir Department of Medicine, All-India Institute of Medical Sciences, New Delhi, India aut Acta diabetologia latina Springer-Verlag 27/4(1990-10-01), 337-342 0001-5563 27:4<337 1990 27 592 https://doi.org/10.1007/BF02580938 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02580938 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lall Shyam Department of Pharmacology, All-India Institute of Medical Sciences, 110 029, New Delhi, India aut NATIONALLICENCE 700 1- Kunchaparty Shanti Department of Pharmacology, All-India Institute of Medical Sciences, 110 029, New Delhi, India aut NATIONALLICENCE 700 1- Siddiqui Hefazat Department of Pharmacology, All-India Institute of Medical Sciences, 110 029, New Delhi, India aut NATIONALLICENCE 700 1- Bajaj Jasbir Department of Medicine, All-India Institute of Medical Sciences, New Delhi, India aut NATIONALLICENCE 773 0- Acta diabetologia latina Springer-Verlag 27/4(1990-10-01), 337-342 0001-5563 27:4<337 1990 27 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer