caa a22 4500 465745539 CHVBK 20180323111819.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02580932 doi (NATIONALLICENCE)springer-10.1007/BF02580932 Antioxidant effect of vanadate on experimental diabetic rats [Elektronische Daten] [Natesanpillai Sekar, Anumanthan Kanthasamy, Samuel William, Natarajan Balasubramaniyan, Saminathan Govindasamy] Summary: The activities of enzymes involved in cellular defence mechanisms such as superoxide dismutase, catalase, glutathione peroxidase and glutathione level have been found to be altered in experimental diabetes. Rats were made diabetic by a single i.v. injection of streptozotocin (55 mg/kg body weight) in citrate buffer. After the onset of diabetes, the diabetic rats were treated with sodium orthovanadate (0.3 mg/ml) for 15 days. Decreased activities of glutathione peroxidase, catalase, superoxide dismutase and glutathione content found in diabetic rats were corrected to near normal. The altered levels of plasma lipid peroxide, glycoproteins and erythrocyte membrane phospholipids in diabetic rats were restored to control levels by vanadate treatment. These observations clearly indicate the antioxidant potential of vanadate on experimental diabetes. Casa Editrice «il Ponte», 1990 Antioxidant nationallicence Diabetes nationallicence Erythrocytes nationallicence Glycoproteins nationallicence Insulin nationallicence Lipid peroxidation nationallicence Vanadate nationallicence Sekar Natesanpillai Department of Biochemistry, University of Madras Guindy Campus, 600 025, Madras, India aut Kanthasamy Anumanthan Department of Biochemistry, University of Madras Guindy Campus, 600 025, Madras, India aut William Samuel Department of Biochemistry, University of Madras Guindy Campus, 600 025, Madras, India aut Balasubramaniyan Natarajan Department of Biochemistry, University of Madras Guindy Campus, 600 025, Madras, India aut Govindasamy Saminathan Department of Biochemistry, University of Madras Guindy Campus, 600 025, Madras, India aut Acta diabetologia latina Springer-Verlag 27/4(1990-10-01), 285-293 0001-5563 27:4<285 1990 27 592 https://doi.org/10.1007/BF02580932 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02580932 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sekar Natesanpillai Department of Biochemistry, University of Madras Guindy Campus, 600 025, Madras, India aut NATIONALLICENCE 700 1- Kanthasamy Anumanthan Department of Biochemistry, University of Madras Guindy Campus, 600 025, Madras, India aut NATIONALLICENCE 700 1- William Samuel Department of Biochemistry, University of Madras Guindy Campus, 600 025, Madras, India aut NATIONALLICENCE 700 1- Balasubramaniyan Natarajan Department of Biochemistry, University of Madras Guindy Campus, 600 025, Madras, India aut NATIONALLICENCE 700 1- Govindasamy Saminathan Department of Biochemistry, University of Madras Guindy Campus, 600 025, Madras, India aut NATIONALLICENCE 773 0- Acta diabetologia latina Springer-Verlag 27/4(1990-10-01), 285-293 0001-5563 27:4<285 1990 27 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer