caa a22 4500 465745547 CHVBK 20180323111819.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02580937 doi (NATIONALLICENCE)springer-10.1007/BF02580937 Intermittent dietary restriction in eSS diabetic rats. Effects on metabolic control and skin morphology [Elektronische Daten] [Stella Martínez, María Tarrés, Silvana Montenegro, Gilda Revelant, Nora Figueroa, Daniel Alonso, Oscar Laudanno, Alberto D'Ottavio] Summary: eSS rats exhibit a non-insulin-dependent diabetic syndrome, significantly influenced by diet. Long-term effects of intermittent dietary restriction were studied in male eSS rats. Experimental animals were fedad libitum during 48h and food-deprived the next 24h (R) while controls (L) of the same strain were freely fed every day. This schedule was maintained from 21 days of age until all rats were sacrificed. R animals were leaner than L rats at 5, 8 and 13 months of age. Moreover, an improved metabolic profile (i.e., lower levels in blood triglycerides, total blood cholesterol, basal blood glucose and blood glucose after an oral glucose load) was found. Histological examination of nuchal skin specimens showed a significant increase of dermal thickness and epidermal hypotrophy in free-fed animals. Collagenous fibers closely packed were found just beneath the dermo-epidermal junction in L rats. This finding was less pronounced in R rats. The above mentioned results suggest that eSS rats would draw advantage from living in environments where food availability is uncertain. The importance of early dietary restrictions in predisposed genotypes appears to be a valuable preventive measure against diabetic evolution and complications. Casa Editrice «il Ponte», 1990 Diabetes nationallicence eSS rats nationallicence Intermittent dietary restriction nationallicence Metabolism nationallicence Skin morphology nationallicence Martínez Stella Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut Tarrés María Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut Montenegro Silvana Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut Revelant Gilda Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut Figueroa Nora Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut Alonso Daniel Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut Laudanno Oscar Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut D'Ottavio Alberto Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut Acta diabetologia latina Springer-Verlag 27/4(1990-10-01), 329-336 0001-5563 27:4<329 1990 27 592 https://doi.org/10.1007/BF02580937 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02580937 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martínez Stella Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut NATIONALLICENCE 700 1- Tarrés María Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut NATIONALLICENCE 700 1- Montenegro Silvana Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut NATIONALLICENCE 700 1- Revelant Gilda Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut NATIONALLICENCE 700 1- Figueroa Nora Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut NATIONALLICENCE 700 1- Alonso Daniel Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut NATIONALLICENCE 700 1- Laudanno Oscar Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut NATIONALLICENCE 700 1- D'Ottavio Alberto Facultad de Ciencias Médicas y Consejo de Investigaciones de la Universidad Nacional de Rosario, Rosario, Argentina aut NATIONALLICENCE 773 0- Acta diabetologia latina Springer-Verlag 27/4(1990-10-01), 329-336 0001-5563 27:4<329 1990 27 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer