caa a22 4500 465745598 CHVBK 20180323111819.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02581289 doi (NATIONALLICENCE)springer-10.1007/BF02581289 The role of hypertension in the development of nephropathy in type 1 (insulin-dependent) diabetes mellitus [Elektronische Daten] [Bo Feldt-Rasmussen, Kirsten Nørgaard, Tonny Jensen, Elisabeth Mathiesen, Torsten Deckert] Summary: Which comes first when developing clinical diabetic nephropathy, the blood pressure rise or the increasing urinary albumin excretion? This issue is discussed based on recent literature of studies in humans with Type 1 (insulin-dependent) diabetes mellitus. We conclude that hypertension has a central role in the progression of diabetic nephropathy and has deleterious effects on the life expectancy of patients who already have signs of diabetic renal disease in terms of elevated urinary albumin excretion. However, blood pressure is preceded by small increments of urinary albumin excretion rates, an indicator of a universally increased vascular leakiness, and thus does not seem to be the cause of diabetic nephropathy. Casa Editrica «il Ponte», 1990 Blood-pressure nationallicence Macroangiopathy nationallicence Microalbuminuria nationallicence Microangiopathy nationallicence Feldt-Rasmussen Bo Steno Memorial Hospital, Niels Steensensvej 2, DK-2820, Gentofte, Denmark aut Nørgaard Kirsten Steno Memorial Hospital, Niels Steensensvej 2, DK-2820, Gentofte, Denmark aut Jensen Tonny Steno Memorial Hospital, Niels Steensensvej 2, DK-2820, Gentofte, Denmark aut Mathiesen Elisabeth Steno Memorial Hospital, Niels Steensensvej 2, DK-2820, Gentofte, Denmark aut Deckert Torsten Steno Memorial Hospital, Niels Steensensvej 2, DK-2820, Gentofte, Denmark aut Acta diabetologia latina Springer-Verlag 27/2(1990-04-01), 173-179 0001-5563 27:2<173 1990 27 592 https://doi.org/10.1007/BF02581289 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02581289 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Feldt-Rasmussen Bo Steno Memorial Hospital, Niels Steensensvej 2, DK-2820, Gentofte, Denmark aut NATIONALLICENCE 700 1- Nørgaard Kirsten Steno Memorial Hospital, Niels Steensensvej 2, DK-2820, Gentofte, Denmark aut NATIONALLICENCE 700 1- Jensen Tonny Steno Memorial Hospital, Niels Steensensvej 2, DK-2820, Gentofte, Denmark aut NATIONALLICENCE 700 1- Mathiesen Elisabeth Steno Memorial Hospital, Niels Steensensvej 2, DK-2820, Gentofte, Denmark aut NATIONALLICENCE 700 1- Deckert Torsten Steno Memorial Hospital, Niels Steensensvej 2, DK-2820, Gentofte, Denmark aut NATIONALLICENCE 773 0- Acta diabetologia latina Springer-Verlag 27/2(1990-04-01), 173-179 0001-5563 27:2<173 1990 27 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer