caa a22 4500 46574561X CHVBK 20180323111819.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02581287 doi (NATIONALLICENCE)springer-10.1007/BF02581287 Comparison of BT-PABA test and fecal chymotrypsin measurements in normal subjects and diabetic patients [Elektronische Daten] [Giuseppe Montalto, Antonio Carroccio, Giovanni Marino, Maurizio Soresi, Cesare Di Marco, Alberto Notarbartolo] Summary: A N-benzoil-L-tyrosil-PABA test on 6h urine collection, a plasma PABA assay 2h after administration and a fecal chymotrypsin assay were performed on 66 patients (36 controls and 30 type 2 diabetic patients on insulin therapy). All patients were hospitalized and without gastrointestinal and renal disease. The mean values of plasmatic PABA and fecal chymotrypsin were significantly lower in the diabetic group than in the controls (p<0.025 and p<0.01, respectively), although they remained within normal range. But this was not the case for PABA urinary excretion values. This may indicate a slower but more protracted PABA absorption during the third or fourth hour with the result that urinary excretion over 6h is not greatly affected. There was good correlation between fecal chymotrypsin values and both PABA urinary excretion values and serum PABA values, a trend observed both in diabetics (p<0.005 and p<0.001, respectively) and in controls (p<0.001 and p<0.005, respectively). This could indicate that even at lower mean levels, the diabetic patients show the same behavior pattern and therefore maintain the same indexes of correlation as the control population. Our results suggest that these indirect, but simple, economical and well-tolerated tests could be considered a valid alternative for investigating pancreatic function especially in those patients that cannot be tested by a Secretin-Cerulein test. Casa Editrica «il Ponte», 1990 BT-PABA test nationallicence Diabetes mellitus nationallicence Fecal chymotrypsin nationallicence Pancreatic function test nationallicence Montalto Giuseppe Cattedra di Patologia Medica, Università degli Studi di Palermo, Palermo, Italy aut Carroccio Antonio Cattedra di Patologia Medica, Università degli Studi di Palermo, Palermo, Italy aut Marino Giovanni Cattedra di Patologia Medica, Università degli Studi di Palermo, Palermo, Italy aut Soresi Maurizio Cattedra di Patologia Medica, Università degli Studi di Palermo, Palermo, Italy aut Di Marco Cesare Cattedra di Patologia Medica, Università degli Studi di Palermo, Palermo, Italy aut Notarbartolo Alberto Cattedra di Patologia Medica, Università degli Studi di Palermo, Palermo, Italy aut Acta diabetologia latina Springer-Verlag 27/2(1990-04-01), 157-163 0001-5563 27:2<157 1990 27 592 https://doi.org/10.1007/BF02581287 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02581287 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Montalto Giuseppe Cattedra di Patologia Medica, Università degli Studi di Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Carroccio Antonio Cattedra di Patologia Medica, Università degli Studi di Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Marino Giovanni Cattedra di Patologia Medica, Università degli Studi di Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Soresi Maurizio Cattedra di Patologia Medica, Università degli Studi di Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Di Marco Cesare Cattedra di Patologia Medica, Università degli Studi di Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Notarbartolo Alberto Cattedra di Patologia Medica, Università degli Studi di Palermo, Palermo, Italy aut NATIONALLICENCE 773 0- Acta diabetologia latina Springer-Verlag 27/2(1990-04-01), 157-163 0001-5563 27:2<157 1990 27 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer