caa a22 4500 465745652 CHVBK 20180323111819.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02581281 doi (NATIONALLICENCE)springer-10.1007/BF02581281 Effect of dietary environment on the development of impaired glucose tolerance and pancreatic hormone secretion in neonatal streptozocin-treated (NSZ) rats [Elektronische Daten] [Yutaka Seino, Masaru Usami, Yoshimasa Okamoto, Taizo Yamamoto, Masaki Ikeda, Tomohiko Taminato, Hiroo Imura] Summary: The effects of four different diets, a balanced (BD), a high protein (HP), a high fat (HF), and a high carbohydrate (HC) diet on glucose tolerance and pancreatic hormone secretion were compared during the ten-week period immediately after weaning in rats having glucose intolerance induced by streptozocin in the neonatal period (NSZ). Feeding HF or HC produced a decrease in calorie intake and a delay in body weight increase. All NSZ rats showed glucose intolerance as adults; the HF rats showed a further deterioration of glucose tolerance and a decreased insulinogenic index after oral glucose loading. Plasma insulin levels of HC rats were lowest. The glucose-induced insulin and somatostatin secretion from the isolated perfused pancreas was almost identical in all four groups. The arginine-induced insulin and glucagon secretion was decreased in HF and HC rats, compared to both HP and BD rats, but somatostatin secretion was not. These results indicate that a high fat or high carbohydrate dietary environment is an important factor in the development of glucose intolerance and in the impairment of pancreatic hormone responsiveness to stimulation. Casa Editrica «il Ponte», 1990 Diet nationallicence Glucose tolerance nationallicence Insulin secretion nationallicence Non-insulin-dependent diabetes mellitus nationallicence Streptozocin nationallicence Seino Yutaka Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606, Kyoto, Japan aut Usami Masaru Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606, Kyoto, Japan aut Okamoto Yoshimasa Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606, Kyoto, Japan aut Yamamoto Taizo Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606, Kyoto, Japan aut Ikeda Masaki Ikeda Hospital, Amagasaki, Hyogo, Japan aut Taminato Tomohiko Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606, Kyoto, Japan aut Imura Hiroo Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606, Kyoto, Japan aut Acta diabetologia latina Springer-Verlag 27/2(1990-04-01), 95-104 0001-5563 27:2<95 1990 27 592 https://doi.org/10.1007/BF02581281 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02581281 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seino Yutaka Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Usami Masaru Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Okamoto Yoshimasa Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Yamamoto Taizo Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Ikeda Masaki Ikeda Hospital, Amagasaki, Hyogo, Japan aut NATIONALLICENCE 700 1- Taminato Tomohiko Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Imura Hiroo Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 773 0- Acta diabetologia latina Springer-Verlag 27/2(1990-04-01), 95-104 0001-5563 27:2<95 1990 27 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer