caa a22 4500 465746330 CHVBK 20180323111821.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00331413 doi (NATIONALLICENCE)springer-10.1007/BF00331413 Electroanalytical study of benzodiazepinooxazoles: Haloxazolam [Elektronische Daten] [F. Rodríguez, R. Jiménez, R. Alonso] Summary: The polarographic behaviour of 10-bromo-11 b-(2-fluorophenyl)-2,3,7,11 b-tetrahydrooxazolo [3,2-d][1,4] benzodiazepin-6(5H)-one (Haloxazolam) was studied in the pH range 1-13. Haloxazolam suffers a hydrolysis process, which can be followed by polarography. The reduction processes of Haloxazolam and its hydrolysis products are irreversible and their currents are diffusion-controlled. This behaviour was compared with that observed for other members of benzodiazepinooxazoles. Two polarographic methods have been developed upon the basis of the reduction of both the protonated iminium form (0.05 mol/l HCl, measurement time: 5 min) and the benzophenone produced in the hydrolysis process (pH 13.25, measurement time: 17 min). The relationship between reduction peak current and concentration is linear up to at least 6.62×10−5 mol/l for both methods. A higher sensitivity was obtained for the method based on the benzophenone reduction (detection limit 1.06×10−7 mol/l; 40 μg/l). The reproducibility of the both methods in terms of relative standard deviation was inferior to 2%. Springer-Verlag, 1990 Rodríguez F. Departamento de Química Analitica, Facultad de Ciencias, Universidad del Pais Vasco, Apdo. 644, E-48 080, Bilbao, Spain aut Jiménez R. Departamento de Química Analitica, Facultad de Ciencias, Universidad del Pais Vasco, Apdo. 644, E-48 080, Bilbao, Spain aut Alonso R. Departamento de Química Analitica, Facultad de Ciencias, Universidad del Pais Vasco, Apdo. 644, E-48 080, Bilbao, Spain aut Fresenius' Journal of Analytical Chemistry Springer-Verlag 336/8(1990-01-01), 672-675 0937-0633 336:8<672 1990 336 216 https://doi.org/10.1007/BF00331413 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00331413 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rodríguez F. Departamento de Química Analitica, Facultad de Ciencias, Universidad del Pais Vasco, Apdo. 644, E-48 080, Bilbao, Spain aut NATIONALLICENCE 700 1- Jiménez R. Departamento de Química Analitica, Facultad de Ciencias, Universidad del Pais Vasco, Apdo. 644, E-48 080, Bilbao, Spain aut NATIONALLICENCE 700 1- Alonso R. Departamento de Química Analitica, Facultad de Ciencias, Universidad del Pais Vasco, Apdo. 644, E-48 080, Bilbao, Spain aut NATIONALLICENCE 773 0- Fresenius' Journal of Analytical Chemistry Springer-Verlag 336/8(1990-01-01), 672-675 0937-0633 336:8<672 1990 336 216 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer