caa a22 4500 465749119 CHVBK 20180323111828.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00322533 doi (NATIONALLICENCE)springer-10.1007/BF00322533 Matrix effects in biological reference materials used in the standardization of cholesterol measurements [Elektronische Daten] [Gary Myers, Parvin Waymack] Summary: The precise and accurate laboratory measurement of blood cholesterol has become a national public health priority in the diagnosis and management of patients at risk for coronary heart disease. Unreliable measurements can hamper the national program to control heart disease. The National Cholesterol Education Program (NCEP) recommends that manufacturers and clinical laboratories achieve traceability to the National Reference System for Cholesterol in order to reliably classify patients according to the NCEP guidelines for assessing coronary heart disease risk. Documenting the accuracy of certain clinical analytical systems for the measurement of cholesterol has been complicated by the occurrence of fluid matrix effects. The major difficulty is that some processed materials (including calibrators, controls, proficiency survey samples, and reference materials) may not be reliable and may result in inaccurate measurement of patient specimens. Similarly, use of such material in accuracy assessment or proficiency testing may yield erroneous conclusions regarding system accuracy. Here, we will review the problem of matrix effects in cholesterol materials and present the results of several studies evaluating sources of matrix error. An alternate approach to documenting accuracy, to be used until commutable materials free of matrix effects are available, will also be discussed. Springer-Verlag, 1990 Myers Gary Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, 30333, Atlanta, Georgia, USA aut Waymack Parvin Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, 30333, Atlanta, Georgia, USA aut Fresenius' Journal of Analytical Chemistry Springer-Verlag 338/4(1990-01-01), 538-542 0937-0633 338:4<538 1990 338 216 https://doi.org/10.1007/BF00322533 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00322533 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Myers Gary Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, 30333, Atlanta, Georgia, USA aut NATIONALLICENCE 700 1- Waymack Parvin Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, 30333, Atlanta, Georgia, USA aut NATIONALLICENCE 773 0- Fresenius' Journal of Analytical Chemistry Springer-Verlag 338/4(1990-01-01), 538-542 0937-0633 338:4<538 1990 338 216 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer