caa a22 4500 465749143 CHVBK 20180323111829.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00322532 doi (NATIONALLICENCE)springer-10.1007/BF00322532 Normal values for chromium (Cr) and nickel (Ni) in human pulmonary tissue [Elektronische Daten] [H. Raithel, K. Schaller] Summary: Especially some relatively insoluble nickel (Ni)-compounds as well as certain chromates may be able to induce cancer in the regions of the lungs, the nose and the paranasal sinuses after occupational exposure. Recent investigations have shown that these metals can cumulate in the lung tissue after inhalation. So the evaluation of normal values is an important precondition for appraisal of Cr and Ni accumulation in lung tissue. In 30 random autopsies, nickel and chromium were determined quantitatively by atomic absorption spectrometry (AAS) in human lung tissue to evaluate normal values. None of the deceased persons had an occupational exposure to Cr and Ni or their compounds. The samples were taken from different segments and lobes of the lungs, taking topographical anatomical criteria into consideration. From the results of 495 tissue samples median chromium concentrations between 742 and 1375 ng/g were calculated, with median nickel concentrations of 107-195 ng/g (dry weight). Concentrations of Cr and Ni were 1.3-1.9 times higher in the upper lung areas. So the results showed substantial variation both within a single lung and also between individuals. In view of the variability in metal concentrations, analysis of only one part of lung tissue is not representative. Springer-Verlag, 1990 Raithel H. Institute of Occupational and Social Medicine of the University of Erlangen-Nürnberg, Schillerstrasse 25/29, D-8520, Erlangen, Federal Republic of Germany aut Schaller K. Institute of Occupational and Social Medicine of the University of Erlangen-Nürnberg, Schillerstrasse 25/29, D-8520, Erlangen, Federal Republic of Germany aut Fresenius' Journal of Analytical Chemistry Springer-Verlag 338/4(1990-01-01), 534-537 0937-0633 338:4<534 1990 338 216 https://doi.org/10.1007/BF00322532 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00322532 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raithel H. Institute of Occupational and Social Medicine of the University of Erlangen-Nürnberg, Schillerstrasse 25/29, D-8520, Erlangen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Schaller K. Institute of Occupational and Social Medicine of the University of Erlangen-Nürnberg, Schillerstrasse 25/29, D-8520, Erlangen, Federal Republic of Germany aut NATIONALLICENCE 773 0- Fresenius' Journal of Analytical Chemistry Springer-Verlag 338/4(1990-01-01), 534-537 0937-0633 338:4<534 1990 338 216 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer