caa a22 4500 465752403 CHVBK 20180323111837.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF01576274 doi (NATIONALLICENCE)springer-10.1007/BF01576274 Sarosdy Michael The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78284-7845, San Antonio, TX, USA aut Do we have a rational treatment plan for stage D-1 carcinoma of the prostate? [Elektronische Daten] [Michael Sarosdy] Summary: After a half century of endocrine therapy for metastatic prostate cancer, it appears that we might still lack an approach to the treatment of stage D-1 disease that is based on scientific study. Although recognized as flawed by most students of prostate cancer, the conclusions of the Veterans Administration Cooperative Urological Research Group (VACURG) studies may have molded our approach to hormonal therapy to a degree that is out of proportion to their scientific validity. Alternative approaches using early hormonal therapy alone or in combination with radical prostatectomy have been received with much more skepticism than the VACURG studies' conclusions. As we enter the era of "total androgen ablation”, it would seem appropriate to review our approach to the treatment of stage D-1 disease. Are we in a position to modify slightly our treatment of this disease, or does closer examination of the foundation of our treatment philosophy suggest that a more critical and systematic study of such patients is warranted? Springer-Verlag, 1990 World Journal of Urology Springer-Verlag 8/1(1990-03-01), 27-33 0724-4983 8:1<27 1990 8 345 https://doi.org/10.1007/BF01576274 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01576274 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Sarosdy Michael The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78284-7845, San Antonio, TX, USA aut NATIONALLICENCE 773 0- World Journal of Urology Springer-Verlag 8/1(1990-03-01), 27-33 0724-4983 8:1<27 1990 8 345 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer