caa a22 4500 465752470 CHVBK 20180323111837.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF01576766 doi (NATIONALLICENCE)springer-10.1007/BF01576766 Partial unilateral ureteric obstruction alters regional renal blood flow [Elektronische Daten] [P. Grace, P. Gillen, D. Dowsett, J. Fitzpatrick] Summary: Complete unilateral ureteric obstruction decreases ipsi-lateral and increases contra-lateral renal blood flow, with shunting of intrarenal blood flow from outer to inner cortical zones. We tested the hypothesis that partial unilateral ureteric obstruction would also result in alterations in renal perfusion patterns. In five dogs, the left ureter was partially obstructed for 4 weeks and then reimplanted into the bladder for a further 4 weeks. Whitaker tests confirmed partial ureteric obstruction. Renal blood flow was assessed at each stage by distribution of radioactively labelled microspheres prior to and following ureteric obstruction and after reimplantation. Partial unilateral ureteric obstruction significantly decreased total blood flow to the ipsi-lateral kidney (51% vs 26%;P<0.05) and increases total blood flow to the contralateral kidney (49% vs 74%;P<0.05). In the ipsilateral kidney, partial ureteric obstruction induced a significant decrease in outer cortical blood flow (57% vs 76%;P<0.01) and a concomitant increase in inner cortical blood flow (35% vs 18%;P<0.02). A similar, albeit less marked, shunting of blood from outer to inner cortex was seen in the contralateral kidney. Relief of sbstruction after 4 weeks did not restore the renal circulation to its pre-obstruction profile. We speculate that the alterations in intrarenal blood flow may be hormonally mediated. Springer-Verlag, 1990 Grace P. Department of Surgery/Urology, Mater Misericordiae Hospital University College, 47 Eccles Street, Dublin, Ireland aut Gillen P. Department of Surgery/Urology, Mater Misericordiae Hospital University College, 47 Eccles Street, Dublin, Ireland aut Dowsett D. Department of Surgery/Urology, Mater Misericordiae Hospital University College, 47 Eccles Street, Dublin, Ireland aut Fitzpatrick J. Department of Surgery/Urology, Mater Misericordiae Hospital University College, 47 Eccles Street, Dublin, Ireland aut World Journal of Urology Springer-Verlag 8/3(1990-09-01), 170-174 0724-4983 8:3<170 1990 8 345 https://doi.org/10.1007/BF01576766 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01576766 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grace P. Department of Surgery/Urology, Mater Misericordiae Hospital University College, 47 Eccles Street, Dublin, Ireland aut NATIONALLICENCE 700 1- Gillen P. Department of Surgery/Urology, Mater Misericordiae Hospital University College, 47 Eccles Street, Dublin, Ireland aut NATIONALLICENCE 700 1- Dowsett D. Department of Surgery/Urology, Mater Misericordiae Hospital University College, 47 Eccles Street, Dublin, Ireland aut NATIONALLICENCE 700 1- Fitzpatrick J. Department of Surgery/Urology, Mater Misericordiae Hospital University College, 47 Eccles Street, Dublin, Ireland aut NATIONALLICENCE 773 0- World Journal of Urology Springer-Verlag 8/3(1990-09-01), 170-174 0724-4983 8:3<170 1990 8 345 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer