caa a22 4500 465752985 CHVBK 20180323111839.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF01600304 doi (NATIONALLICENCE)springer-10.1007/BF01600304 The immunopathology of Schistosoma mansoni granulomas in human colonic schistosomiasis [Elektronische Daten] [K. Geboes, I. El-Dosoky, A. El-Wahab, K. Almagd] Summary: The immunopathology ofSchistosoma mansoni infection was studied in colonic biopsies obtained from 14 patients with established schistosomiasis. The characteristic lesions of this parasitic infection are mainly induced by the presence of living eggs in the tissue. Different types of lesions can be present simultaneously. The earliest lesions contain T-lymphocytes as well as accessory cells around living eggs. They transform into granulomas composed of eosinophils, T-lymphocytes, a few B-lymphocytes and large mononuclear cells expressing major histocompatibility (MHC) class II antigens. These cells are also Mac 387 positive. This means that they are monocytes/macrophages freshly recruited from the blood. In other, probably older, granulomas, MHC class II positive cells tend to disappear and the centrally located multinucleated giant cells are negative for antibodies directed against MHC class II antigens. It appears thus that the composition of the granulomas in schistosomiasis is variable. The lesions may have characteristics of cell-mediated immunity and/or of a foreign-body reaction. Contrary to what is often seen in Crohn's disease or intestinal tuberculosis no major hyperplasia of the lymphoid tissue is observed in the colon in association withS. mansoni infection. Springer-Verlag, 1990 Schistosoma mansoni nationallicence Immunopathology nationallicence Colon nationallicence Granuloma nationallicence Geboes K. Laboratory of Histo- and Cytochemistry, University Hospital St. Rafaël, Minderbroedersstraat 12, B-3000, Leuven, Belgium aut El-Dosoky I. Department of Pathology, Mansoura University, Egypt aut El-Wahab A. Department of Gastroenterology, Mansoura University, Egypt aut Almagd K. Department of Gastroenterology, Mansoura University, Egypt aut Virchows Archiv A Springer-Verlag 416/6(1990-11-01), 527-534 0174-7398 416:6<527 1990 416 428 https://doi.org/10.1007/BF01600304 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01600304 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Geboes K. Laboratory of Histo- and Cytochemistry, University Hospital St. Rafaël, Minderbroedersstraat 12, B-3000, Leuven, Belgium aut NATIONALLICENCE 700 1- El-Dosoky I. Department of Pathology, Mansoura University, Egypt aut NATIONALLICENCE 700 1- El-Wahab A. Department of Gastroenterology, Mansoura University, Egypt aut NATIONALLICENCE 700 1- Almagd K. Department of Gastroenterology, Mansoura University, Egypt aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/6(1990-11-01), 527-534 0174-7398 416:6<527 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer