caa a22 4500 465753051 CHVBK 20180323111839.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF01600297 doi (NATIONALLICENCE)springer-10.1007/BF01600297 Morphometric comparison of mitochondria and myofibrils of cardiomyocytes between hypertrophic and dilated cardiomyopathies [Elektronische Daten] [Atsushi Tashiro, Tomoyuki Masuda, Ikuo Segawa] Summary: We performed an ultrastructural, morphometric comparison of mitochondria and myofibrils of cardiomyocytes using endomyocardial biopsy specimens in hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Biopsies came from the right ventricular side of the interventricular septum in nine patients with HCM, nine with DCM, and nine controls with arrhythmia and/or ST depression. Morphometric analysis was carried out using electron microscopic photographs and an image analyser. Mitochondria were significantly greater in number and smaller in size in HCM than in the control group. In DCM, the size of mitochondria was also significantly smaller than in the control group, although their number was similar to that of the control group. No statistically significant difference was found regarding the size of mitochondria between HCM and DCM. The percentages of both mitochondrial and myofibrillar areas in cytoplasm were smaller in the DCM than the HCM and control groups, though no difference was seen between the latter two. The ratio of mitochondrial area to myofibrillar area was almost the same in each group. These results suggest increased mitochondrial function to match hypertrophic cardiomyocytes in HCM, and decreased mitochondrial function and cardiomyocytic contractility in DCM. Springer-Verlag, 1990 Cardiomyopathies nationallicence Ultrastructure nationallicence Morphometry nationallicence Mitochondria nationallicence Myofibrils nationallicence Tashiro Atsushi Departments of Pathology and Medicine, Iwate Medical University School of Medicine, Uchimaru 19-1, 020, Morioka, Japan aut Masuda Tomoyuki Departments of Pathology and Medicine, Iwate Medical University School of Medicine, Uchimaru 19-1, 020, Morioka, Japan aut Segawa Ikuo Departments of Pathology and Medicine, Iwate Medical University School of Medicine, Uchimaru 19-1, 020, Morioka, Japan aut Virchows Archiv A Springer-Verlag 416/6(1990-11-01), 473-478 0174-7398 416:6<473 1990 416 428 https://doi.org/10.1007/BF01600297 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01600297 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tashiro Atsushi Departments of Pathology and Medicine, Iwate Medical University School of Medicine, Uchimaru 19-1, 020, Morioka, Japan aut NATIONALLICENCE 700 1- Masuda Tomoyuki Departments of Pathology and Medicine, Iwate Medical University School of Medicine, Uchimaru 19-1, 020, Morioka, Japan aut NATIONALLICENCE 700 1- Segawa Ikuo Departments of Pathology and Medicine, Iwate Medical University School of Medicine, Uchimaru 19-1, 020, Morioka, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/6(1990-11-01), 473-478 0174-7398 416:6<473 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer