caa a22 4500 46575306X CHVBK 20180323111839.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF01600306 doi (NATIONALLICENCE)springer-10.1007/BF01600306 Metastasizing neuroendocrine carcinoma of the larynx with calcitonin and somatostatin secretion and CEA production, resembling medullary thyroid carcinoma [Elektronische Daten] [G. Smets, F. Warson, M. Dehou, G. Storme, R. Sacré, S. Van Belle, G. Somers, W. Gepts, G. Klöppel] Summary: A 55-year-old man presented with a metastasizing moderately differentiated neuroendocrine carcinoma of the larynx (atypical carcinoid). Immunocytochemical demonstration of neuroendocrine markers (neuron-specific enolase and chromogranin-A) and presence of membrane-bound neurosecretory granules in the cells established the neuroendocrine nature of the tumour. In addition, the tumour was found to produce calcitonin, somatostatin and carcino-embryonic antigen (CEA). Calcitonin and somatostatin were also secreted. On the basis of this particular marker constellation the tumour closely resembles medullary thyroid carcinoma. Review of the recent literature on carcinoids of the larynx reveals immunoreactivity for calcitonin and CEA in a high percentage of cases. Springer-Verlag, 1990 Laryngeal neuroendocrine carcinoma nationallicence Carcinoid nationallicence Calcitonin nationallicence Somatostatin nationallicence Carcino-embryonic antigen nationallicence Smets G. Department of Pathology, Academic Hospital, Free University of Brussels, Laarbeeklaan 101, B-1090, Brussels, Belgium aut Warson F. Department of Pathology, OCMW Hospital, St Elisabeth, Aalst, Belgium aut Dehou M. Department of Pathology, Academic Hospital, Free University of Brussels, Laarbeeklaan 101, B-1090, Brussels, Belgium aut Storme G. Department of Oncology, Academic Hospital, Free University of Brussels, Brussels, Belgium aut Sacré R. Department of Surgery, Academic Hospital, Free University of Brussels, Brussels, Belgium aut Van Belle S. Department of Oncology, Academic Hospital, Free University of Brussels, Brussels, Belgium aut Somers G. Department of Internal Medicine, Academic Hospital, Free University of Brussels, Brussels, Belgium aut Gepts W. Department of Pathology, Academic Hospital, Free University of Brussels, Laarbeeklaan 101, B-1090, Brussels, Belgium aut Klöppel G. Department of Pathology, Academic Hospital, Free University of Brussels, Laarbeeklaan 101, B-1090, Brussels, Belgium aut Virchows Archiv A Springer-Verlag 416/6(1990-11-01), 539-543 0174-7398 416:6<539 1990 416 428 https://doi.org/10.1007/BF01600306 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01600306 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Smets G. Department of Pathology, Academic Hospital, Free University of Brussels, Laarbeeklaan 101, B-1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Warson F. Department of Pathology, OCMW Hospital, St Elisabeth, Aalst, Belgium aut NATIONALLICENCE 700 1- Dehou M. Department of Pathology, Academic Hospital, Free University of Brussels, Laarbeeklaan 101, B-1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Storme G. Department of Oncology, Academic Hospital, Free University of Brussels, Brussels, Belgium aut NATIONALLICENCE 700 1- Sacré R. Department of Surgery, Academic Hospital, Free University of Brussels, Brussels, Belgium aut NATIONALLICENCE 700 1- Van Belle S. Department of Oncology, Academic Hospital, Free University of Brussels, Brussels, Belgium aut NATIONALLICENCE 700 1- Somers G. Department of Internal Medicine, Academic Hospital, Free University of Brussels, Brussels, Belgium aut NATIONALLICENCE 700 1- Gepts W. Department of Pathology, Academic Hospital, Free University of Brussels, Laarbeeklaan 101, B-1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Klöppel G. Department of Pathology, Academic Hospital, Free University of Brussels, Laarbeeklaan 101, B-1090, Brussels, Belgium aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/6(1990-11-01), 539-543 0174-7398 416:6<539 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer