caa a22 4500 465753108 CHVBK 20180323111839.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF01678984 doi (NATIONALLICENCE)springer-10.1007/BF01678984 Evidence for cytomegalovirus and human immunodeficiency virus infection of the retina in AIDS [Elektronische Daten] [Annette Schmitt-Gräff, Eva Neuen-Jacob, Barbara Rettig, Rainer Sundmacher] Summary: Characteristic ophthalmopathological features of retinal lesions in a patient with the acquired immunodeficiency syndrome (AIDS) are reported. In situ hybridization, immunohistochemistry and electron microscopy revealed severe unilateral cytomegalovirus (CMV) retinitis. The opposite retina which was not involved by CMV showed nonspecific signs of ischaemia in the nerve fiber layer corresponding to cotton-wool spots. Occasional cells of both retinas were positively stained by a mouse monoclonal antibody to the p24 HIV-1 antigen indicating infection of retinal cells by HIV. It is suggested that HIV may directly or indirectly damage retinal tissue and interact with opportunistic pathogens, thus leading to a variety of ocular abnormalities associated with AIDS. Springer-Verlag, 1990 Human immunodeficiency virus nationallicence Opportunisitc ocular infections nationallicence AIDS-associated retinopathy nationallicence Schmitt-Gräff Annette Department of Pathology, University of Düsseldorf, Düsseldorf, Federal Republic of Germany aut Neuen-Jacob Eva Department of Neuropathology, University of Düsseldorf, Düsseldorf, Federal Republic of Germany aut Rettig Barbara Department of Pathology, University of Düsseldorf, Düsseldorf, Federal Republic of Germany aut Sundmacher Rainer Department of Ophthalmology, University of Düsseldorf, Düsseldorf, Federal Republic of Germany aut Virchows Archiv A Springer-Verlag 416/3(1990-05-01), 249-253 0174-7398 416:3<249 1990 416 428 https://doi.org/10.1007/BF01678984 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01678984 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schmitt-Gräff Annette Department of Pathology, University of Düsseldorf, Düsseldorf, Federal Republic of Germany aut NATIONALLICENCE 700 1- Neuen-Jacob Eva Department of Neuropathology, University of Düsseldorf, Düsseldorf, Federal Republic of Germany aut NATIONALLICENCE 700 1- Rettig Barbara Department of Pathology, University of Düsseldorf, Düsseldorf, Federal Republic of Germany aut NATIONALLICENCE 700 1- Sundmacher Rainer Department of Ophthalmology, University of Düsseldorf, Düsseldorf, Federal Republic of Germany aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/3(1990-05-01), 249-253 0174-7398 416:3<249 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer