caa a22 4500 465753116 CHVBK 20180323111839.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF01678982 doi (NATIONALLICENCE)springer-10.1007/BF01678982 Anaplastic large cell lymphoma, CD30/Ki-1 positive, expressing the CD15/Leu-M1 antigen [Elektronische Daten] Immunohistochemical and morphological relationships to Hodgkin's disease [R. Rosso, M. Paulli, U. Magrini, S. Kindl, E. Boveri, G. Volpato, S. Poggi, P. Baglioni, S. Pileri] Summary: In this report we analyze the morphological and immunohistochemical findings observed in 5 cases of CD30/Ki-1 positive anaplastic large cell lymphoma, a recently recognized neoplastic entity. In comparison with the Ki-1 lymphomas so far described, these cases showed a fairly large number of Reed-Sternberg-like cells, often admixed with small lymphocytes and occasional eosinophils. Moreover, in all our cases immunohistochemical reactions detected the CD15/ Leu-M1 antigen, together with markers of the T-lineage and of lymphoid activation. In previous studies the CD15/Leu-M1 antigen has been found in the majority of cases of Hodgkin's disease, but has been stated to be absent typically in Ki-1 lymphomas. Our results indicate that this antigen cannot be considered a reliable tool to distinguish between Ki-1 lymphomas and Hodgkin's disease. Furthermore, the morphological and immunohistochemical findings reported suggest that in some cases Ki-1 cell lymphoma and Hodgkin's disease may be closely related. They may represent different steps in the progression of the same lymphoproliferative disorder. Springer-Verlag, 1990 Anaplastic large cell lymphoma nationallicence Non-Hodgkin's lymphoma nationallicence Immunohistochemistry nationallicence Antigen expression nationallicence Rosso R. Department of Human Pathology, Anatomic Pathology Section, University of Pavia, Italy aut Paulli M. Department of Pathology, IRCCS Policlinico S. Matteo, Pavia, Italy aut Magrini U. Department of Human Pathology, Anatomic Pathology Section, University of Pavia, Italy aut Kindl S. Department of Human Pathology, Anatomic Pathology Section, University of Pavia, Italy aut Boveri E. Department of Human Pathology, Anatomic Pathology Section, University of Pavia, Italy aut Volpato G. Department of Surgery, University of Pavia, Italy aut Poggi S. Department of Haematology "L. and A. Seragnoli”, Haemolymphopathology Section, University of Bologna, Italy aut Baglioni P. Department of Haematology "L. and A. Seragnoli”, Haemolymphopathology Section, University of Bologna, Italy aut Pileri S. Department of Haematology "L. and A. Seragnoli”, Haemolymphopathology Section, University of Bologna, Italy aut Virchows Archiv A Springer-Verlag 416/3(1990-05-01), 229-235 0174-7398 416:3<229 1990 416 428 https://doi.org/10.1007/BF01678982 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01678982 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rosso R. Department of Human Pathology, Anatomic Pathology Section, University of Pavia, Italy aut NATIONALLICENCE 700 1- Paulli M. Department of Pathology, IRCCS Policlinico S. Matteo, Pavia, Italy aut NATIONALLICENCE 700 1- Magrini U. Department of Human Pathology, Anatomic Pathology Section, University of Pavia, Italy aut NATIONALLICENCE 700 1- Kindl S. Department of Human Pathology, Anatomic Pathology Section, University of Pavia, Italy aut NATIONALLICENCE 700 1- Boveri E. Department of Human Pathology, Anatomic Pathology Section, University of Pavia, Italy aut NATIONALLICENCE 700 1- Volpato G. Department of Surgery, University of Pavia, Italy aut NATIONALLICENCE 700 1- Poggi S. Department of Haematology "L. and A. Seragnoli”, Haemolymphopathology Section, University of Bologna, Italy aut NATIONALLICENCE 700 1- Baglioni P. Department of Haematology "L. and A. Seragnoli”, Haemolymphopathology Section, University of Bologna, Italy aut NATIONALLICENCE 700 1- Pileri S. Department of Haematology "L. and A. Seragnoli”, Haemolymphopathology Section, University of Bologna, Italy aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/3(1990-05-01), 229-235 0174-7398 416:3<229 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer