caa a22 4500 465753124 CHVBK 20180323111839.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF01678981 doi (NATIONALLICENCE)springer-10.1007/BF01678981 Altered expression of Lewis blood group and related antigens in fetal, normal adult and malignant tissues of the uterine endometrium [Elektronische Daten] [Masaki Inoue, Masahiro Nakayama, Osamu Tanizawa] Summary: The expression of the Lewis blood group and its related antigens in fetal, normal adult and malignant tissues of the uterine endometrium was examined immunohistochemically using a panel of mouse monoclonal antibodies with specificities for Lewis-a (La), Sialyl Lewis-a (SLa), Lewis-b (Lb), Lewis-X (LX), Sialyl Lewis-X (SLX) and Lewis-Y (LY) antigens. La, SLa and SLX having one fucose residue were detected in a small number of fetal tissues, while Lb and LY having two fucose residues were found in most cases. In the adult endometrium, expression of Lb and LY was considerably lower than those in fetal tissues, although expression of La and SLa was not different between these two tissues. Expression of LX and SLX was pronouned in adult when compared with fetal tissues. Malignant endometrial glands expressed La, SLa, Lb and LY, extensively, while LX and SLX were expressed less than in normal tissues. Lb and LY can thus be considered oncofetal antigens, extensively expressed in fetal and malignant tissues but not in normal adult tissues. Expression of Lb and LY was greater than that of La and SLA in carcinoma; an increase in the activity of fucose transferase might be associated with malignant transformation in the uterine endometrium. Springer-Verlag, 1990 Carbohydrate antigen nationallicence Lewis blood group antigen nationallicence Endometrial cancer nationallicence Fucosetransferase nationallicence Inoue Masaki Department of Obstetrics and Gynecology, Osaka University Medical School, 1-1-50 Fukushima, Fukushima-ku, 553, Osaka, Japan aut Nakayama Masahiro Department of Pathology, Osaka Medical Center for Maternal and Child Health, Osaka, Japan aut Tanizawa Osamu Department of Obstetrics and Gynecology, Osaka University Medical School, 1-1-50 Fukushima, Fukushima-ku, 553, Osaka, Japan aut Virchows Archiv A Springer-Verlag 416/3(1990-05-01), 221-228 0174-7398 416:3<221 1990 416 428 https://doi.org/10.1007/BF01678981 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01678981 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inoue Masaki Department of Obstetrics and Gynecology, Osaka University Medical School, 1-1-50 Fukushima, Fukushima-ku, 553, Osaka, Japan aut NATIONALLICENCE 700 1- Nakayama Masahiro Department of Pathology, Osaka Medical Center for Maternal and Child Health, Osaka, Japan aut NATIONALLICENCE 700 1- Tanizawa Osamu Department of Obstetrics and Gynecology, Osaka University Medical School, 1-1-50 Fukushima, Fukushima-ku, 553, Osaka, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/3(1990-05-01), 221-228 0174-7398 416:3<221 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer