caa a22 4500 465753132 CHVBK 20180323111839.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF01678987 doi (NATIONALLICENCE)springer-10.1007/BF01678987 Measles associated with coronary arteritis [Elektronische Daten] [Yasuo Takano, Hideharu Manabe, Yuzo Aoyama, Noboru Nakamichi, Toshiharu Matsumura, Takeshi Kurata] Summary: A two-year-old girl with measles virus (MV) and chronic Epstein-Barr virus (EBV) infection developed lethal coronary aneurysmal arteritis accompanied by giant cell pneumonia, systemic lymphadenitis and hepatosplenomegaly. In her coronary arteries, lungs and aorta, cells containing intranuclear and intracytoplasmic inclusions, including syncytial giant cells, were detected, the presence of MV in the organs being proved by electron microscopic and immunofluorescent studies. Immunopathology further demonstrated MV to be disseminated in almost all organs other than lymph nodes. Clinical diagnosis of chronic EBV infection was established on the basis of persistent high titers of antibodies against capsid and early antigens of EBV and viral presence was confirmed by Southern blot hybridization in a mesenterial lymph node obtained at autopsy. To the best of our knowledge, this is the first description of MV association with coronary aneurysmal arteritis, raising the possibility that measles infection can cause severe vasculitis under immuno-suppressive states, such as that caused by chronic EBV infection. Springer-Verlag, 1990 Measles nationallicence Coronary arteritis nationallicence Epstein nationallicence Barr virus nationallicence Takano Yasuo Department of Pathology, Odawara Municipal Hospital, 46 Kuno, Odawara, 250, Kanagawa, Japan aut Manabe Hideharu Department of Pediatrics, Odawara Municipal Hospital, 46 Kuno, Odawara, 250, Kanagawa, Japan aut Aoyama Yuzo Department of Pathology, Odawara Municipal Hospital, 46 Kuno, Odawara, 250, Kanagawa, Japan aut Nakamichi Noboru Division of Gerontology and Nutrition, Meiji Institute of Health Science, 540 Naruda, Odawara, 250, Kanagawa, Japan aut Matsumura Toshiharu Division of Gerontology and Nutrition, Meiji Institute of Health Science, 540 Naruda, Odawara, 250, Kanagawa, Japan aut Kurata Takeshi Department of Pathology, Japanese National Institute of Health, 2-10-35 Kamiousaki, Sinagawa-ku, 141, Tokyo, Japan aut Virchows Archiv A Springer-Verlag 416/3(1990-05-01), 271-276 0174-7398 416:3<271 1990 416 428 https://doi.org/10.1007/BF01678987 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01678987 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takano Yasuo Department of Pathology, Odawara Municipal Hospital, 46 Kuno, Odawara, 250, Kanagawa, Japan aut NATIONALLICENCE 700 1- Manabe Hideharu Department of Pediatrics, Odawara Municipal Hospital, 46 Kuno, Odawara, 250, Kanagawa, Japan aut NATIONALLICENCE 700 1- Aoyama Yuzo Department of Pathology, Odawara Municipal Hospital, 46 Kuno, Odawara, 250, Kanagawa, Japan aut NATIONALLICENCE 700 1- Nakamichi Noboru Division of Gerontology and Nutrition, Meiji Institute of Health Science, 540 Naruda, Odawara, 250, Kanagawa, Japan aut NATIONALLICENCE 700 1- Matsumura Toshiharu Division of Gerontology and Nutrition, Meiji Institute of Health Science, 540 Naruda, Odawara, 250, Kanagawa, Japan aut NATIONALLICENCE 700 1- Kurata Takeshi Department of Pathology, Japanese National Institute of Health, 2-10-35 Kamiousaki, Sinagawa-ku, 141, Tokyo, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/3(1990-05-01), 271-276 0174-7398 416:3<271 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer