caa a22 4500 465753221 CHVBK 20180323111839.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01605295 doi (NATIONALLICENCE)springer-10.1007/BF01605295 Expression of epidermal growth factor receptor in normal colorectal mucosa, adenoma, and carcinoma [Elektronische Daten] [Karin Koretz, Peter Schlag, Peter Möller] Summary: Using the monoclonal antibody EGFR1, the expression of epidermal growth factor receptor (EGFR) was investigated immunohistochemically in normal colonic mucosa distant from and adjacent to colonic neoplasms, in 25 adenomas and in 144 unselected colorectal carcinomas. EGFR expression was an inconsistant phenomenon in each of these conditions. It was not expressed in 23/44 non-neoplastic mucosa specimens distant from and in 26/44 mucosae adjacent to colon tumours; 15/25 adenomas and 71 (49.3%) of the carcinomas failed to contain detectable amounts of EGFR. In contrast, large amounts of EGFR were found in 4 non-neoplastic mucosae at both locations, in 3 adenomas and in 11 (7.6%) carcinomas. The remaining cases showed complex patterns of EGFR-expression. In comparing mucosae close to and distant from a colonic tumour, only minor differences in EGFR content were observed. The intra-individual comparison of the mode of EGFR expression in non-neoplastic and neoplastic epithelium revealed an overexpression of EGFR in carcinomas in about one third of the 44 cases examined. One third showed no obvious differences, and one third showed lower levels of EGFR expression within the tumour. We conclude that the mode of EGFR expression in normal and neoplastic colon epithelium is variable and reflective of inter-individual constitutive differences rather than of abnormalities in gene regulation. Statistical analysis failed to reveal correlations between the mode of EGFR expression and tumour grade, type or Dukes stage. Springer-Verlag, 1990 Epidermal growth factor receptor (EGFR) nationallicence Colorectal mucosa nationallicence Colorectal adenoma nationallicence Colorectal carcinoma nationallicence Koretz Karin Pathologisches Institut, Im Neuenheimer Feld, D-6900, Heidelberg, Federal Republic of Germany aut Schlag Peter Chirurgische Klinik der Universität Heidelberg, Im Neuenheimer Feld, D-6900, Heidelberg, Federal Republic of Germany aut Möller Peter Pathologisches Institut, Im Neuenheimer Feld, D-6900, Heidelberg, Federal Republic of Germany aut Virchows Archiv A Springer-Verlag 416/4(1990-07-01), 343-349 0174-7398 416:4<343 1990 416 428 https://doi.org/10.1007/BF01605295 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605295 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koretz Karin Pathologisches Institut, Im Neuenheimer Feld, D-6900, Heidelberg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Schlag Peter Chirurgische Klinik der Universität Heidelberg, Im Neuenheimer Feld, D-6900, Heidelberg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Möller Peter Pathologisches Institut, Im Neuenheimer Feld, D-6900, Heidelberg, Federal Republic of Germany aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/4(1990-07-01), 343-349 0174-7398 416:4<343 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer