caa a22 4500 465753256 CHVBK 20180323111839.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01605294 doi (NATIONALLICENCE)springer-10.1007/BF01605294 Amyloid in intervertebral discs of surgery and autopsy material [Elektronische Daten] A new class of amyloid? [Andreas Wullbrand, Wolfgang Saeger, Hans-Peter Missmahl, Claudia Voigt, Reinhold Linke] Summary: Intervertebral discs from 82 consecutive operations on herniation and 59 autopsies (one case with generalized amyloidosis) were studied. Amyloid deposits observed in surgical and autopsy specimens increased with age in both series. Degenerative changes were related to age and to amyloid deposits in autopsy, but not in surgical cases. Calcium pyrophosphate dihydrate deposits (often in proximity to amyloid deposits) were found in autopsy discs of six patients and in surgical specimens of three patients with previous operations on herniated discs. Antisera against amyloid fibril proteins of different types including AA-, Aλ-, Aκ, AF- and AB-types showed no reaction with disc amyloid. In one case with generalized Aλ-amyloidosis the disc amyloid was not of the Aλ-type. Based on our results, we suppose that disc amyloid is a form of localized senile amyloidosis — possibly representing a new class of amyloid limited to cartilage tissue. Springer-Verlag, 1990 Amyloidosis nationallicence Immunohistochemistry nationallicence Intervertebral disc nationallicence Wullbrand Andreas Department of Pathology, Marienkrankenhaus Hamburg, Alfredstrasse 9, D-2000, Hamburg 76, Federal Republic of Germany aut Saeger Wolfgang Department of Pathology, Marienkrankenhaus Hamburg, Alfredstrasse 9, D-2000, Hamburg 76, Federal Republic of Germany aut Missmahl Hans-Peter Department of Internal Medicine, Marienkrankenhaus Hamburg, Alfredstrasse 9, D-2000, Hamburg 76, Federal Republic of Germany aut Voigt Claudia Department of Pathology, Marienkrankenhaus Hamburg, Alfredstrasse 9, D-2000, Hamburg 76, Federal Republic of Germany aut Linke Reinhold Institute of Immunology, University of Munich, Goethestrasse 31, D-8000, München 2, Federal Republic of Germany aut Virchows Archiv A Springer-Verlag 416/4(1990-07-01), 335-341 0174-7398 416:4<335 1990 416 428 https://doi.org/10.1007/BF01605294 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605294 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wullbrand Andreas Department of Pathology, Marienkrankenhaus Hamburg, Alfredstrasse 9, D-2000, Hamburg 76, Federal Republic of Germany aut NATIONALLICENCE 700 1- Saeger Wolfgang Department of Pathology, Marienkrankenhaus Hamburg, Alfredstrasse 9, D-2000, Hamburg 76, Federal Republic of Germany aut NATIONALLICENCE 700 1- Missmahl Hans-Peter Department of Internal Medicine, Marienkrankenhaus Hamburg, Alfredstrasse 9, D-2000, Hamburg 76, Federal Republic of Germany aut NATIONALLICENCE 700 1- Voigt Claudia Department of Pathology, Marienkrankenhaus Hamburg, Alfredstrasse 9, D-2000, Hamburg 76, Federal Republic of Germany aut NATIONALLICENCE 700 1- Linke Reinhold Institute of Immunology, University of Munich, Goethestrasse 31, D-8000, München 2, Federal Republic of Germany aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/4(1990-07-01), 335-341 0174-7398 416:4<335 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer