caa a22 4500 465753264 CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01605290 doi (NATIONALLICENCE)springer-10.1007/BF01605290 Basement membrane changes in atrophic tubules in the human kidney [Elektronische Daten] [Gerda Goovaerts, Marc De Broe, Norbert Buyssens] Summary: Changes in the basement membrane (BM) in atrophic tubules in human kidney biopsies were studied by electron microscopy and by immunohistochemistry on cryostat sections with antibodies against collagen type I, type III, type IV, laminin, EMA, keratin and vimentin. The BM showed different degrees of thickening with formation of reduplications which contained fibrocytes. Remnants of cytoplasm of epithelial cells and fibrocytes were incorporated in the thickened BM. This showed signs of lysis and disintegration, indicating that the redundant BM formed by the epithelial cells is removed, although imperfectly, by interstitial cells. Thinning of the BM was another frequent finding. Immunohistochemistry showed a clear reactivity for collagen type IV and laminin in all BM material. The epithelial cells showed multilayering and a peculiar type of dark cells extending underneath adjacent cells and separating them from their BM attachment. Springer-Verlag, 1990 Kidney nationallicence Tubulus nationallicence Atrophy nationallicence Basement membrane nationallicence Goovaerts Gerda Department of Pathology, University Hospital Antwerp, University of Antwerp, U.I.A., Wilrijkstraat 10, B-5220, Edegem-Antwerpen, Belgium aut De Broe Marc Department of Nephrology and Hypertension, University Hospital Antwerp, University of Antwerp, U.I.A., Wilrijkstraat 10, B-5220, Edegem-Antwerpen, Belgium aut Buyssens Norbert Department of Pathology, University Hospital Antwerp, University of Antwerp, U.I.A., Wilrijkstraat 10, B-5220, Edegem-Antwerpen, Belgium aut Virchows Archiv A Springer-Verlag 416/4(1990-07-01), 295-303 0174-7398 416:4<295 1990 416 428 https://doi.org/10.1007/BF01605290 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605290 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goovaerts Gerda Department of Pathology, University Hospital Antwerp, University of Antwerp, U.I.A., Wilrijkstraat 10, B-5220, Edegem-Antwerpen, Belgium aut NATIONALLICENCE 700 1- De Broe Marc Department of Nephrology and Hypertension, University Hospital Antwerp, University of Antwerp, U.I.A., Wilrijkstraat 10, B-5220, Edegem-Antwerpen, Belgium aut NATIONALLICENCE 700 1- Buyssens Norbert Department of Pathology, University Hospital Antwerp, University of Antwerp, U.I.A., Wilrijkstraat 10, B-5220, Edegem-Antwerpen, Belgium aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/4(1990-07-01), 295-303 0174-7398 416:4<295 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer