caa a22 4500 465753280 CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01605298 doi (NATIONALLICENCE)springer-10.1007/BF01605298 Diffuse sclerosing variant of papillary thyroid carcinoma [Elektronische Daten] S-100 protein immunocytochemistry and prognosis [Sören Schröder, Volker Bay, Klaus Dumke, Bernhard Kremens, Hans-Wilhelm Müller-Gärtner, Werner Böcker, Hartwig Kastendieck] Summary: The recently published second edition of the WHO classification of thyroid tumours describes the diffuse sclerosing papillary carcinoma (DSPC) as a specific variant of papillary thyroid cancer (PC). Besides several histological hallmarks, this rare tumour is characterized by its occurrence in young individuals and is thought to have a less favourable prognosis than PC in general. The observations on two examples of this tumour presented herein, however, are at variance at this assumption. The neoplasms occurred in a 10 year old girl and a 34 year old woman. Each time, diffuse involvement of both thyroid lobes and bilateral cervical lymphadenopathy were seen. In one case, the carcinoma extended into the cervical soft tissue. Follow-up disclosed both patients to be without evidence of disease 2 and 13 years, respectively, after thyroid surgery. Immunocytochemically, both thyroid primaries as well as 7 other cases of DSPC reported in the literature showed dense accumulations of S-100 protein positive dendritic/Langerhans cells. Such infiltrations have been demonstrated to be correlated with a benign clinical course of PC. It is thus suggested that DSPC behaves similarly or even less aggressively than PC in general, at least if prominent Langerhans cell infiltration is present. Springer-Verlag, 1990 Papillary thyroid carcinoma nationallicence Diffuse sclerosing variant nationallicence S-100 protein nationallicence Prognosis nationallicence Langerhans cells nationallicence Schröder Sören Institute of Pathology, University of Hamburg (UKE), Martinistrasse 52, D-2000, Hamburg 20, Federal Republic of Germany aut Bay Volker Department of Surgery, General Hospital Harburg, D-2100, Hamburg 90 aut Dumke Klaus Institutes of Pathology, Hospital Gilead, D-4800, Bielefeld 13 aut Kremens Bernhard Department of Pediatrics, University of Essen, D-4300, Essen 1 aut Müller-Gärtner Hans-Wilhelm Department of Nuclear Medicine, University of Hamburg, D-2000, Hamburg 20 aut Böcker Werner Institutes of Pathology, University of Münster, D-4400, Münster aut Kastendieck Hartwig Institutes of Pathology, General Hospital Harburg, D-2100, Hamburg 90 aut Virchows Archiv A Springer-Verlag 416/4(1990-07-01), 367-371 0174-7398 416:4<367 1990 416 428 https://doi.org/10.1007/BF01605298 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605298 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schröder Sören Institute of Pathology, University of Hamburg (UKE), Martinistrasse 52, D-2000, Hamburg 20, Federal Republic of Germany aut NATIONALLICENCE 700 1- Bay Volker Department of Surgery, General Hospital Harburg, D-2100, Hamburg 90 aut NATIONALLICENCE 700 1- Dumke Klaus Institutes of Pathology, Hospital Gilead, D-4800, Bielefeld 13 aut NATIONALLICENCE 700 1- Kremens Bernhard Department of Pediatrics, University of Essen, D-4300, Essen 1 aut NATIONALLICENCE 700 1- Müller-Gärtner Hans-Wilhelm Department of Nuclear Medicine, University of Hamburg, D-2000, Hamburg 20 aut NATIONALLICENCE 700 1- Böcker Werner Institutes of Pathology, University of Münster, D-4400, Münster aut NATIONALLICENCE 700 1- Kastendieck Hartwig Institutes of Pathology, General Hospital Harburg, D-2100, Hamburg 90 aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/4(1990-07-01), 367-371 0174-7398 416:4<367 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer