caa a22 4500 465753310 CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01605289 doi (NATIONALLICENCE)springer-10.1007/BF01605289 Immunohistochemical study of possible changes in keratin expression during neoplastic transformation of the uterine mucosa [Elektronische Daten] [Anne Gernow, Bjarne Nielsen, Berit Hølund, Per Clausen] Summary: The present study aimed to examine possible changes in keratin expression during neoplastic transformation of the uterine mucosa and possible differences in keratin expression between endocervical and endometrial adenocarcinomas. Routinely processed specimens with normal morphology or neoplastic changes were stained immunohistochemically using 5 commercial antibodies to keratinfilaments of molecular weight 39-58 kD: CAM 5.2, RCK 102, MCA 144, PKE and PRE. We generally found a change in keratin expression during the neoplastic transformation, consisting of pronounced heterogeneity compared with normal epithelia. In distinguishing koilocytic atypia from CIN, RCK 102 (52.5, 58 Kd) may prove helpful as it stains neoplastic cells strongly and shows no reaction in koilocytes. Staining with the antibody CAM 5.2 (reactive with 39, 43, 50 kD filaments) may aid in distinguishing between cervical and endometrial adenocarcinomas. The former is stained uniformly; the latter shows a more variable staining. Springer-Verlag, 1990 Cervix nationallicence Endometrium nationallicence Keratins nationallicence Immunohistochemistry nationallicence Gernow Anne Department of Pathology, University Hospital of Odense, Denmark aut Nielsen Bjarne Department of Pathology, University Hospital of Odense, Denmark aut Hølund Berit Department of Pathology, University Hospital of Odense, Denmark aut Clausen Per Department of Pathology, University Hospital of Odense, Denmark aut Virchows Archiv A Springer-Verlag 416/4(1990-07-01), 287-293 0174-7398 416:4<287 1990 416 428 https://doi.org/10.1007/BF01605289 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605289 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gernow Anne Department of Pathology, University Hospital of Odense, Denmark aut NATIONALLICENCE 700 1- Nielsen Bjarne Department of Pathology, University Hospital of Odense, Denmark aut NATIONALLICENCE 700 1- Hølund Berit Department of Pathology, University Hospital of Odense, Denmark aut NATIONALLICENCE 700 1- Clausen Per Department of Pathology, University Hospital of Odense, Denmark aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/4(1990-07-01), 287-293 0174-7398 416:4<287 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer