caa a22 4500 465753329 CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01605288 doi (NATIONALLICENCE)springer-10.1007/BF01605288 Spindle cell reaction to nontuberculous mycobacteriosis in AIDS mimicking a spindle cell neoplasm [Elektronische Daten] Evidence for dual histiocytic and fibroblast-like characteristics of spindle cells [Margaret Brandwein, Ho-Soon Choi, James Strauchen, Mark Stoler, Jaishree Jagirdar] Summary: We report 5 patients with AIDS who had an unusual spindle cell proliferation in the lymph nodes and skin caused by nontuberculous mycobacteriosis. The spindle cell proliferation in these tissues may mimic a spindle cell neoplasm and pose a diagnostic problem if an infectious aetiology is not suspected. The fibroblast-like spindle cells contained numerous acid fast bacilli. They were strongly positive for antibody markers of monocyte/macrophage and leukocyte derivation: Leu M3, Mo-9, T-200, and HLA-DR, and variably positive for alpha-1 anti-chymotrypsin and lysozyme. Ultrastructurally these spindle cells were predominantly fibroblast-like with poorly developed features of macrophages. These results reveal the dual macrophage and fibroblastic character of the spindle cells and probably imply a functional differentiation rather than a histogenetic one. Springer-Verlag, 1990 Mycobacteria nationallicence Spindle cells nationallicence Facultative fibroblasts nationallicence AIDS nationallicence Brandwein Margaret Department of Pathology, Mount Sinai School of Medicine, New York, NY aut Choi Ho-Soon Department of Pathology, Mount Sinai School of Medicine, New York, NY aut Strauchen James Department of Pathology, Mount Sinai School of Medicine, New York, NY aut Stoler Mark Department of Pathology, University of Rochester Strong Memorial Hospital, Rochester, NY, USA aut Jagirdar Jaishree Department of Pathology, Mount Sinai School of Medicine, New York, NY aut Virchows Archiv A Springer-Verlag 416/4(1990-07-01), 281-286 0174-7398 416:4<281 1990 416 428 https://doi.org/10.1007/BF01605288 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605288 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brandwein Margaret Department of Pathology, Mount Sinai School of Medicine, New York, NY aut NATIONALLICENCE 700 1- Choi Ho-Soon Department of Pathology, Mount Sinai School of Medicine, New York, NY aut NATIONALLICENCE 700 1- Strauchen James Department of Pathology, Mount Sinai School of Medicine, New York, NY aut NATIONALLICENCE 700 1- Stoler Mark Department of Pathology, University of Rochester Strong Memorial Hospital, Rochester, NY, USA aut NATIONALLICENCE 700 1- Jagirdar Jaishree Department of Pathology, Mount Sinai School of Medicine, New York, NY aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/4(1990-07-01), 281-286 0174-7398 416:4<281 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer