caa a22 4500 465753337 CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF01605141 doi (NATIONALLICENCE)springer-10.1007/BF01605141 Cytoskeletal characteristics of myofibroblasts in benign neoplastic and reactive fibroblastic lesions [Elektronische Daten] [Tadashi Hasegawa, Takanori Hirose, Eiji Kudo, Jun-ichi Abe, Kazuo Hizawa] Summary: The characteristics of the cytoskeleton of myofibroblasts were examined immunohistochemically in 10 extra-abdominal desmoid tumours, 3 palmar and 2 plantar fibromatoses and 5 nodular fasciites; in the cultured cells of one desmoid tumour, and also ultrastructurally in 3 desmoid tumours. Polyclonal anti-desmin antibody reacted with the cells in 7 extra-abdominal desmoid tumours, 1 palmar fibromatosis, 1 plantar fibromatosis and 3 nodular fasciites. Monoclonal antidesmin antibody reacted with cells in only 2 desmoid tumours. Desmin-positive spindle cells were scattered throughout these lesions. There were no marked ultrastructural differences between desmin-positive and desmin-negative desmoids. All specimens except one specimen of nodular fasciitis showed immunoreactivity for alpha-smooth muscle actin and vimentin. Muscle actin-positive cells were observed in all specimens. Cultured cells gave positive reactions with polyclonal desmin antibody as well as to vimentin antibodies and two preparations of actin antibodies, whereas the original tumour did not react with desmin antibody. The present studies suggested that the cytoskeleton of some myofibroblasts in both neoplastic and reactive lesions resembles that of smooth muscle cells. Springer-Verlag, 1990 Myofibroblast nationallicence Cytoskeleton nationallicence Desmoid tumour nationallicence Desmin nationallicence Immunohistochemistry nationallicence Hasegawa Tadashi First Department of Pathology, The University of Tokushima School of Medicine, Kuramoto-cho 3, 770, Tokushima, Japan aut Hirose Takanori First Department of Pathology, The University of Tokushima School of Medicine, Kuramoto-cho 3, 770, Tokushima, Japan aut Kudo Eiji First Department of Pathology, The University of Tokushima School of Medicine, Kuramoto-cho 3, 770, Tokushima, Japan aut Abe Jun-ichi First Department of Pathology, The University of Tokushima School of Medicine, Kuramoto-cho 3, 770, Tokushima, Japan aut Hizawa Kazuo First Department of Pathology, The University of Tokushima School of Medicine, Kuramoto-cho 3, 770, Tokushima, Japan aut Virchows Archiv A Springer-Verlag 416/5(1990-09-01), 375-382 0174-7398 416:5<375 1990 416 428 https://doi.org/10.1007/BF01605141 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605141 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hasegawa Tadashi First Department of Pathology, The University of Tokushima School of Medicine, Kuramoto-cho 3, 770, Tokushima, Japan aut NATIONALLICENCE 700 1- Hirose Takanori First Department of Pathology, The University of Tokushima School of Medicine, Kuramoto-cho 3, 770, Tokushima, Japan aut NATIONALLICENCE 700 1- Kudo Eiji First Department of Pathology, The University of Tokushima School of Medicine, Kuramoto-cho 3, 770, Tokushima, Japan aut NATIONALLICENCE 700 1- Abe Jun-ichi First Department of Pathology, The University of Tokushima School of Medicine, Kuramoto-cho 3, 770, Tokushima, Japan aut NATIONALLICENCE 700 1- Hizawa Kazuo First Department of Pathology, The University of Tokushima School of Medicine, Kuramoto-cho 3, 770, Tokushima, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/5(1990-09-01), 375-382 0174-7398 416:5<375 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer