caa a22 4500 46575337X CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF01605152 doi (NATIONALLICENCE)springer-10.1007/BF01605152 Nerve fibre proliferation in interstitial cystitis [Elektronische Daten] [T. Christmas, J. Rode, C. Chapple, E. Milroy, R. Turner-Warwick] Summary: The aetiology of pain in interstitial cystitis is not understood, although it has been reported to be due to release of mediators from mast cell granules. Cystolysis and intravesical instillation of dimethyl sulphoxide have been shown to relieve pain in this condition. We have studied the nerve population within the bladder wall using immunohistochemical stains for protein gene product 9.5. A group of 18 cases of chronic interstitial cystitis and 12 controls; neuropathic bladder (n=1), chronic bacterial cystitis (n=3), systemic lupus erythematosus cystitis (n=2) and normals (n=6), were investigated. There were significantly more nerve fibres within the sub-urothelial and detrusor muscle layers in chronic interstitial cystitis than there were in normals. Patients with chronic cystitis of other aetiology did not have a significant increase in nerve fibre density within the bladder wall suggesting a specific association between nerve fibre proliferation and interstitial cystitis. Cystolysis is shown to deplete selectively the submucosal nerve plexuses without altering the nerve density within detrusor muscle. This finding explains the desensitisation of the bladder without impairment of detrusor function after this procedure. Springer-Verlag, 1990 Interstitial cystitis nationallicence Bladder nerves nationallicence Protein gene product 9.5 nationallicence cystolysis nationallicence Christmas T. Department of Urology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, W1N 8AA, London, UK aut Rode J. Department of Histopathology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, W1N 8AA, London, UK aut Chapple C. Department of Urology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, W1N 8AA, London, UK aut Milroy E. Department of Urology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, W1N 8AA, London, UK aut Turner-Warwick R. Department of Urology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, W1N 8AA, London, UK aut Virchows Archiv A Springer-Verlag 416/5(1990-09-01), 447-451 0174-7398 416:5<447 1990 416 428 https://doi.org/10.1007/BF01605152 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605152 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Christmas T. Department of Urology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, W1N 8AA, London, UK aut NATIONALLICENCE 700 1- Rode J. Department of Histopathology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, W1N 8AA, London, UK aut NATIONALLICENCE 700 1- Chapple C. Department of Urology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, W1N 8AA, London, UK aut NATIONALLICENCE 700 1- Milroy E. Department of Urology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, W1N 8AA, London, UK aut NATIONALLICENCE 700 1- Turner-Warwick R. Department of Urology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, W1N 8AA, London, UK aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/5(1990-09-01), 447-451 0174-7398 416:5<447 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer