caa a22 4500 46575340X CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF01605143 doi (NATIONALLICENCE)springer-10.1007/BF01605143 Colonic mucosal changes in nude mice associated with orthotopic xenografts of human colon cancer cells [Elektronische Daten] [Koji Sekikawa, Jan Arends, Kees Verstijnen, Joop ten Kate, Bert Schutte, Fred Bosnian] Summary: We used the nude mouse tumour xenograft model to study the pathogenesis of mucosa alterations in the large bowel surrounding a carcinoma. In mouse colonic mucosa overlying HT-29 colonic carcinoma xenografts in the caecum, the crypts were elongated in comparison with those in distant mucosa and also frequently showed a shift towards sialomucin production. These features, which are comparable with socalled transitional mucosa (TM) in man, were absent in control animals inoculated with Indian Ink instead of HT-29 cells. Although the localization of the proliferative cell compartment in mouse colonic mucosa overlying HT-29 xenografts appeared to be confined to the lower half of the crypt as in normal mucosa, the relative length of the DNA synthesizing cell compartment along the crypts was slightly elongated. These data strongly suggest that TM should be regarded as a secondary phenomenon rather than a premalignant change in large intestinal epithelium and that higher proliferative activity of epithelial cells contributes little to the elongation of crypts in TM. Springer-Verlag, 1990 Transitional mucosa nationallicence Colon carcinoma nationallicence Nude mice nationallicence Xenografts nationallicence Sekikawa Koji Department of Pathology, University of Limburg, Maastricht, The Netherlands aut Arends Jan Departments of Pathology and Cell Biology, University of Limburg, Maastricht, The Netherlands aut Verstijnen Kees Departments of Pathology and Cell Biology, University of Limburg, Maastricht, The Netherlands aut ten Kate Joop Departments of Pathology and Cell Biology, University of Limburg, Maastricht, The Netherlands aut Schutte Bert Departments of Pathology and Cell Biology, University of Limburg, Maastricht, The Netherlands aut Bosnian Fred University of Limburg, Maastricht, The Netherlands aut Virchows Archiv A Springer-Verlag 416/5(1990-09-01), 393-396 0174-7398 416:5<393 1990 416 428 https://doi.org/10.1007/BF01605143 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605143 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sekikawa Koji Department of Pathology, University of Limburg, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Arends Jan Departments of Pathology and Cell Biology, University of Limburg, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Verstijnen Kees Departments of Pathology and Cell Biology, University of Limburg, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- ten Kate Joop Departments of Pathology and Cell Biology, University of Limburg, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Schutte Bert Departments of Pathology and Cell Biology, University of Limburg, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Bosnian Fred University of Limburg, Maastricht, The Netherlands aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/5(1990-09-01), 393-396 0174-7398 416:5<393 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer