caa a22 4500 465753426 CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF01605144 doi (NATIONALLICENCE)springer-10.1007/BF01605144 Immunohistochemical localization of factor X-like antigen in pancreatic islets and their tumours [Elektronische Daten] [Cesare Bordi, Ji-Yao Yu, Antonio Girolami, Corrado Betterle] Summary: The authors have investigated by immunohistochemistry the distribution of factor X-like antigen in normal pancreatic islets and in a series of 46 pancreatic endocrine tumours. It was found that both glucagon-producing (A) cells and pancreatic polypeptide-producing (PP) cells are immunoreactive for the antigen. Benign glucagonomas and PP-omas presented the highest concentrations of immunoreactive material whose intracellular distribution was consistent with localization within cell secretory granules. Some benign insulinomas also presented factor X immunostaining in spite of the absence of the antigen in normal insulin-producing B cells. Although malignant tumours usually exhibited very low or no immunostaining, two of three malignant glucagonomas showed scattered, intensely immunoreactive cells. The factor X-like antigen identified in this study was found to differ from chromogranin A and B. The possible implications of the present findings for coagulative disorders associated with glucagonomas or diabetes are discussed. Springer-Verlag, 1990 Factor X nationallicence Pancreatic endocrine tumours nationallicence Islet A cells nationallicence Islet PP cells nationallicence Immunocytochemistry nationallicence Bordi Cesare Istituto di Anatomia Patologica, Università di Parma, I-43100, Parma, Italy aut Yu Ji-Yao Istituto di Anatomia Patologica, Università di Parma, I-43100, Parma, Italy aut Girolami Antonio Chair of Medical Pathology II, Institute of Medical Semeiotics, University of Padua, Padua, Italy aut Betterle Corrado Chair of Medical Semeiotics, Institute of Medical Semeiotics, University of Padua, Padua, Italy aut Virchows Archiv A Springer-Verlag 416/5(1990-09-01), 397-402 0174-7398 416:5<397 1990 416 428 https://doi.org/10.1007/BF01605144 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605144 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bordi Cesare Istituto di Anatomia Patologica, Università di Parma, I-43100, Parma, Italy aut NATIONALLICENCE 700 1- Yu Ji-Yao Istituto di Anatomia Patologica, Università di Parma, I-43100, Parma, Italy aut NATIONALLICENCE 700 1- Girolami Antonio Chair of Medical Pathology II, Institute of Medical Semeiotics, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Betterle Corrado Chair of Medical Semeiotics, Institute of Medical Semeiotics, University of Padua, Padua, Italy aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/5(1990-09-01), 397-402 0174-7398 416:5<397 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer