caa a22 4500 465753442 CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF01605147 doi (NATIONALLICENCE)springer-10.1007/BF01605147 Augmented enkephalin-immunoreactivity in adrenaline-producing phaeochromocytomas [Elektronische Daten] [Takaya Kodama, Chiaki Ito, Yoshihide Fujimoto, Yukio Ito, Takao Obara, Akira Hirayama] Summary: Immunohistochemical studies for methionine- and leucine-enkephalin were performed on 26 phaeochromocytomas to elucidate the patho-physiological roles of enkephalins. Positive reactions were seen in all phaeochromocytomas with varying intensities. The location of methionine- and leucine-enkephalin agreed fairly well with each other. Stronger immunostaining was obtained in phaeochromocytomas secreting both adrenalin and noradrenalin than in those secreting predominantly noradrenalin. Paroxysmal hypertension was frequently observed in patients with adrenalin-secreting phaeochromocytomas, especially those with marked enkephalin positivity. Urinary excretion of metanephrine was significantly correlated with enkephalin positivity. These findings show that all phaeochromocytomas retain the ability to produce enkephalins of the adreno-medullary or extra-medullary chromaffin tissues from which they derive. Augmented enkephalin-immunoreactivity in adrenalin-producing phaeochromocytomas may be interpreted as reflecting a close association of enkephalins with adrenalin under physiological conditions. Springer-Verlag, 1990 Enkephalin nationallicence Phaeochromocytoma nationallicence Kodama Takaya Department of Endocrine Surgery, Tokyo Women's Medical College, Kawadacho 8-1, Shinjukuku, 162, Tokyo, Japan aut Ito Chiaki Department of Endocrine Surgery, Tokyo Women's Medical College, Kawadacho 8-1, Shinjukuku, 162, Tokyo, Japan aut Fujimoto Yoshihide Department of Endocrine Surgery, Tokyo Women's Medical College, Kawadacho 8-1, Shinjukuku, 162, Tokyo, Japan aut Ito Yukio Department of Endocrine Surgery, Tokyo Women's Medical College, Kawadacho 8-1, Shinjukuku, 162, Tokyo, Japan aut Obara Takao Department of Endocrine Surgery, Tokyo Women's Medical College, Kawadacho 8-1, Shinjukuku, 162, Tokyo, Japan aut Hirayama Akira Department of Surgical Pathology, Tokyo Women's Medical College, Kawadacho 8-1, Shinjukuku, 162, Tokyo, Japan aut Virchows Archiv A Springer-Verlag 416/5(1990-09-01), 417-422 0174-7398 416:5<417 1990 416 428 https://doi.org/10.1007/BF01605147 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605147 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kodama Takaya Department of Endocrine Surgery, Tokyo Women's Medical College, Kawadacho 8-1, Shinjukuku, 162, Tokyo, Japan aut NATIONALLICENCE 700 1- Ito Chiaki Department of Endocrine Surgery, Tokyo Women's Medical College, Kawadacho 8-1, Shinjukuku, 162, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujimoto Yoshihide Department of Endocrine Surgery, Tokyo Women's Medical College, Kawadacho 8-1, Shinjukuku, 162, Tokyo, Japan aut NATIONALLICENCE 700 1- Ito Yukio Department of Endocrine Surgery, Tokyo Women's Medical College, Kawadacho 8-1, Shinjukuku, 162, Tokyo, Japan aut NATIONALLICENCE 700 1- Obara Takao Department of Endocrine Surgery, Tokyo Women's Medical College, Kawadacho 8-1, Shinjukuku, 162, Tokyo, Japan aut NATIONALLICENCE 700 1- Hirayama Akira Department of Surgical Pathology, Tokyo Women's Medical College, Kawadacho 8-1, Shinjukuku, 162, Tokyo, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/5(1990-09-01), 417-422 0174-7398 416:5<417 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer