caa a22 4500 465753469 CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF01605151 doi (NATIONALLICENCE)springer-10.1007/BF01605151 Adrenomedullary hyperplasia and phaeochromocytoma. DNA cytophotometric findings in 47 cases [Elektronische Daten] [Barbara-Christina Padberg, Esther Garbe, Eike Achilles, Henning Dralle, Max Bressel, Sören Schröder] Summary: Fifty adrenalectomy specimens containing normal (n=3), hyperplastic (n=4) or neoplastic (n=43) medullary tissue were subjected to quantitative cytophotometric measurements of DNA content. Differing evaluation schemes were applied for interpretation of DNA distribution patterns. Of the 43 phaeochromocytomas (PCC), 16 were inherited as part of the syndrome of multiple endocrine neoplasia type 2a (MEN 2a). Five of 27 sporadic PCCs followed a malignant course. Three benign and three malignant PCCs lacked endocrine activity. In normal medulla and in adrenomedullary hyperplasia, diploid or euploid DNA distributions were found. In contrast, 87% (33/38) of the benign and all 5 malignant PCCs exhibited non-diploid or aneuploid DNA histograms. No differences in DNA content existed between functioning and non-functioning PCCs or between sporadic and hereditary tumours. In this study, in contrast to earlier communications, DNA cytophotometry did not discriminate between benign and malignant adrenomedullary tumours. In addition, as opposed to the findings in a variety of other endocrine tumours, DNA measurements did not appear to be a useful tool to assess the prognosis of an individual malignant PCC. Springer-Verlag, 1990 Adrenal gland nationallicence Phaeochromocytoma nationallicence DNA cytophotometry nationallicence Prognosis nationallicence Padberg Barbara-Christina Institute of Pathology, University of Hamburg, Germany aut Garbe Esther Institute of Pathology, University of Hamburg, Germany aut Achilles Eike Institute of Pathology, University of Hamburg, Germany aut Dralle Henning Department of Surgery, Hannover School of Medicine, Germany aut Bressel Max Department of Urology, General Hospital Hamburg-Harburg, Germany aut Schröder Sören Institute of Pathology, University of Hamburg, Germany aut Virchows Archiv A Springer-Verlag 416/5(1990-09-01), 443-446 0174-7398 416:5<443 1990 416 428 https://doi.org/10.1007/BF01605151 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605151 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Padberg Barbara-Christina Institute of Pathology, University of Hamburg, Germany aut NATIONALLICENCE 700 1- Garbe Esther Institute of Pathology, University of Hamburg, Germany aut NATIONALLICENCE 700 1- Achilles Eike Institute of Pathology, University of Hamburg, Germany aut NATIONALLICENCE 700 1- Dralle Henning Department of Surgery, Hannover School of Medicine, Germany aut NATIONALLICENCE 700 1- Bressel Max Department of Urology, General Hospital Hamburg-Harburg, Germany aut NATIONALLICENCE 700 1- Schröder Sören Institute of Pathology, University of Hamburg, Germany aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 416/5(1990-09-01), 443-446 0174-7398 416:5<443 1990 416 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer